R3 213+ Cheap flights from Knoxville

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
TYS — CPT
Jan 10 — Jan 171
1 adult
1 adult, Economy, 0 bags

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Cheapest flights from Knoxville
Explore the most affordable flight options available from Knoxville. Find the lowest fares based on data from user searches, with prices last updated on 11 December 2025.

Fri 20/319:39TYS - JNB
2 stops32h 46mAmerican Airlines
Wed 25/319:35JNB - TYS
2 stops30h 30mAmerican Airlines
Deal found 10/12R20 993
Sun 18/116:00TYS - CPT
2 stops37h 10mMultiple Airlines
Tue 27/120:50CPT - TYS
2 stops32h 19mMultiple Airlines
Deal found 9/12R21 979
Sun 18/114:37TYS - CPT
1 stop21h 38mVirgin Atlantic
Tue 27/121:30CPT - TYS
1 stop33h 15mVirgin Atlantic
Deal found 9/12R23 288
Fri 1/518:22TYS - CPT
2 stops34h 38mAmerican Airlines
Wed 13/518:50CPT - TYS
2 stops28h 43mAmerican Airlines
Deal found 8/12R24 563
Fri 23/117:15TYS - JNB
2 stops34h 10mBritish Airways
Sun 25/119:35JNB - TYS
2 stops28h 14mBritish Airways
Deal found 8/12R24 665
Fri 30/116:00TYS - CPT
2 stops37h 10mBritish Airways
Tue 3/218:55CPT - TYS
2 stops28h 54mBritish Airways
Deal found 8/12R26 960
Sun 18/116:00TYS - CPT
2 stops33h 05mBritish Airways
Tue 27/120:50CPT - TYS
2 stops32h 19mBritish Airways
Deal found 9/12R27 674
Tue 27/16:20TYS - JNB
2 stops43h 20mQatar Airways
Sat 31/113:45JNB - TYS
2 stops38h 11mQatar Airways
Deal found 9/12R29 323
Fri 20/319:07TYS - JNB
1 stop17h 53mVirgin Atlantic
Wed 25/321:55JNB - TYS
1 stop26h 25mVirgin Atlantic
Deal found 10/12R32 671
Fri 20/37:15TYS - JNB
3 stops34h 00mMultiple Airlines
Wed 25/320:30JNB - TYS
2 stops33h 29mMultiple Airlines
Deal found 10/12R34 252
Tue 27/17:44TYS - JNB
2 stops40h 51mMultiple Airlines
Sat 31/114:30JNB - TYS
3 stops31h 19mMultiple Airlines
Deal found 9/12R37 125
Fri 1/515:03TYS - CPT
2 stops37h 57mMultiple Airlines
Wed 13/514:35CPT - TYS
3 stops30h 07mMultiple Airlines
Deal found 8/12R37 278

Find flights from Knoxville within your budget

 
Find flights departing from Knoxville that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 11 December 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Cape Town

Route

Depart

Return

Price

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Fri 20/3

19:39-10:25

2 stops32h 46m

Johannesburg OR Tambo

Wed 25/3

19:35-20:05

2 stops30h 30m

R20 993

KnoxvilleCape Town

TYS - CPT

TYSCPT

Knoxville McGhee Tyson

Sun 18/1

16:00-12:10

2 stops37h 10m

Cape Town Intl

Tue 27/1

20:50-22:09

2 stops32h 19m

R21 979

KnoxvilleCape Town

TYS - CPT

TYSCPT

Knoxville McGhee Tyson

Sun 18/1

14:37-19:15

1 stop21h 38m

Cape Town Intl

Tue 27/1

21:30-23:45

1 stop33h 15m

R23 288

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Fri 23/1

17:14-10:25

2 stops34h 11m

Johannesburg OR Tambo

Sun 25/1

22:00-18:46

2 stops27h 46m

R24 665

KnoxvilleCape Town

TYS - CPT

TYSCPT

Knoxville McGhee Tyson

Fri 30/1

16:00-12:10

2 stops37h 10m

Cape Town Intl

Tue 3/2

18:55-16:49

2 stops28h 54m

R26 960

KnoxvilleCape Town

TYS - CPT

TYSCPT

Knoxville McGhee Tyson

Sun 18/1

16:00-8:05

2 stops33h 05m

Cape Town Intl

Tue 27/1

20:50-22:09

2 stops32h 19m

R27 674

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Tue 27/1

6:20-8:40

2 stops43h 20m

Johannesburg OR Tambo

Sat 31/1

13:45-20:56

2 stops38h 11m

R29 323

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Fri 20/3

19:07-19:00

1 stop17h 53m

Johannesburg OR Tambo

Wed 25/3

21:55-18:20

1 stop26h 25m

R32 671

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Fri 20/3

7:15-23:15

3 stops34h 00m

Johannesburg OR Tambo

Wed 25/3

20:30-23:59

2 stops33h 29m

R34 252

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Tue 27/1

7:44-7:35

2 stops40h 51m

Johannesburg OR Tambo

Sat 31/1

14:30-14:49

3 stops31h 19m

R37 125

Flights are sorted by cheapest return flights first.

Deals found on 9/12

Showing 1-10 of 18 results
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Best time to book a flight from Knoxville

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Estimated return price
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Travel insights for flights from Knoxville

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Related info for your journey

Access useful and relevant information related to your journey from Knoxville. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 11 December 2025.

  • What are the most popular destinations to fly to from Knoxville?

    The most selected flight destinations from Knoxville for the current month are Denver, Fort Lauderdale, Boston. While Denver, Fort Lauderdale, Boston are the top choices made by travellers year-round.

  • How does Cheapflights help users find flights from Knoxville?

    Cheapflights makes it easy to find flights from Knoxville by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

  • Why should you use Cheapflights to find cheap flight tickets from Knoxville?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Knoxville.

  • Can Cheapflights find flights from Knoxville with no change fees?

    Yes, we can. To see specific flights from Knoxville with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Knoxville become cheaper?

    Of course! You can now track prices for flights from Knoxville and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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How does Cheapflights help users find flights from Knoxville?

Cheapflights makes it easy to find flights from Knoxville by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Knoxville?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Knoxville.

Can Cheapflights find flights from Knoxville with no change fees?

Yes, we can. To see specific flights from Knoxville with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Knoxville become cheaper?

Of course! You can now track prices for flights from Knoxville and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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