R1 397+ Cheap flights from Des Moines

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 18/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — JNB
Feb 24 — Mar 31
1 adult
1 adult, Economy, 0 bags

What to know about flights from Des Moines

Discover essential information about flights departing from Des Moines, including flight schedules, destinations, airlines operating at the Des Moines airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 25 January 2026.

Good one-way deal

R1 676 or less
Price to beat on a one-way flight from Des Moines.
Search Deals

Find flights from Des Moines

Enter your travel dates to find the best prices.

Cheapest flights from Des Moines
Explore the most affordable flight options available from Des Moines. Find the lowest fares based on data from user searches, with prices last updated on 25 January 2026.

Mon 9/319:44
DSM
-
JNB
2 stops28h 51m
Multiple Airlines
Mon 16/319:35
JNB
-
DSM
2 stops35h 05m
Multiple Airlines
Deal found 23/1R19 608
Mon 9/319:44
DSM
-
JNB
2 stops31h 41m
American Airlines
Mon 16/319:35
JNB
-
DSM
2 stops29h 03m
American Airlines
Deal found 23/1R19 753
Tue 10/318:08
DSM
-
JNB
2 stops30h 27m
American Airlines
Tue 17/319:35
JNB
-
DSM
2 stops30h 22m
American Airlines
Deal found 24/1R19 849
Sun 8/319:44
DSM
-
JNB
2 stops31h 41m
American Airlines
Sun 15/319:35
JNB
-
DSM
2 stops30h 22m
American Airlines
Deal found 23/1R20 299
Wed 11/313:52
DSM
-
JNB
2 stops34h 43m
American Airlines
Wed 18/319:35
JNB
-
DSM
2 stops30h 22m
American Airlines
Deal found 24/1R20 588
Tue 24/318:08
DSM
-
JNB
2 stops31h 32m
Qatar Airways
Tue 31/312:40
JNB
-
DSM
2 stops33h 16m
Qatar Airways
Deal found 24/1R20 861

Find flights from Des Moines within your budget

 
Find flights departing from Des Moines that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 25 January 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 9/3

19:44-7:35

2 stops28h 51m

Johannesburg OR Tambo

Mon 16/3

19:35-23:40

2 stops35h 05m

R19 608

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 9/3

19:44-7:35

2 stops28h 51m

Johannesburg OR Tambo

Mon 16/3

19:35-17:38

2 stops29h 03m

R19 753

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 10/3

18:08-7:35

2 stops30h 27m

Johannesburg OR Tambo

Tue 17/3

19:35-18:57

2 stops30h 22m

R19 849

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 8/3

19:44-10:25

2 stops31h 41m

Johannesburg OR Tambo

Sun 15/3

19:35-18:57

2 stops30h 22m

R20 299

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 11/3

13:52-7:35

2 stops34h 43m

Johannesburg OR Tambo

Wed 18/3

19:35-18:57

2 stops30h 22m

R20 588

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 24/3

18:08-8:40

2 stops31h 32m

Johannesburg OR Tambo

Tue 31/3

12:40-14:56

2 stops33h 16m

R20 861

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 10/3

18:08-7:35

2 stops30h 27m

R14 052

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 10/3

11:33-19:00

1 stop24h 27m

R19 142

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 10/3

14:04-9:30

3 stops36h 26m

R20 411

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 5/5

18:45-8:35

2 stops30h 50m

R67 608

Flights are sorted by cheapest return flights first.

Deals found on 24/1

Showing 1-10 of 14 results
1
2

Best time to book a flight from Des Moines

Have a flexible travel schedule? Discover the best time to fly from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines

Get recent, data-driven insights about flights from Des Moines including ideal travel times, pricing trends, and more.

What are popular destinations to fly to from Des Moines?

From Des Moines you can expect to find greater availability for the following destinations: Chicago (440 flights per day), Detroit (126 flights per day) and Dallas (117 flights per day).

Denver Intl
Denver Intl
From R1 676

What is the cheapest place to fly to from Des Moines?

The cheapest city to fly to from Des Moines is Denver Intl, with prices starting at R1 676. Explore other affordable destinations below.

Denver Intl
Denver Intl
From R1 676

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Direct flights from Iowa

Book a direct flight from one of these other cities located in Iowa.
Direct flights from Cedar Rapids

Related info for your journey

Access useful and relevant information related to your journey from Des Moines. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 25 January 2026.

  • What are the most popular destinations to fly to from Des Moines?

    The most selected flight destinations from Des Moines for the current month are Fort Lauderdale, Cancún, Denver. While Denver, Cancún, Nashville are the top choices made by travellers year-round.

  • What is the cheapest flight from Des Moines to anywhere?

    Users have flown out of Des Moines for as low as R1 676 to Denver (prices may vary depending on the airline and departure time). On average, users have booked flights for R1 676 to fly from Des Moines.

  • How does Cheapflights help users find flights from Des Moines?

    Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Des Moines?

    Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

  • Can Cheapflights find flights from Des Moines with no change fees?

    Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

  • Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

    Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

See more FAQs

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Des Moines?

Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines?

Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Des Moines with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book With Flexibility

Our users can plan ahead with confidence and find flights with no change fees.

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.