R3 692+ Cheap flights from Des Moines

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — JNB
Jan 12 — Jan 191
1 adult
1 adult, Economy, 0 bags

What to know about flights from Des Moines

Discover essential information about flights departing from Des Moines, including flight schedules, destinations, airlines operating at the Des Moines airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 13 December 2025.

Good one-way deal

R1 760 or less
Price to beat on a one-way flight from Des Moines.
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Cheapest flights from Des Moines
Explore the most affordable flight options available from Des Moines. Find the lowest fares based on data from user searches, with prices last updated on 13 December 2025.

Sun 25/117:01DSM - JNB
2 stops33h 24mMultiple Airlines
Sun 1/219:35JNB - DSM
2 stops33h 29mMultiple Airlines
Deal found 11/12R20 367
Tue 27/117:01DSM - JNB
2 stops30h 34mMultiple Airlines
Tue 3/222:00JNB - DSM
2 stops33h 23mMultiple Airlines
Deal found 13/12R20 418
Sun 25/117:51DSM - JNB
2 stops32h 34mAmerican Airlines
Sun 1/222:00JNB - DSM
2 stops44h 50mAmerican Airlines
Deal found 10/12R20 738
Tue 27/117:01DSM - JNB
2 stops30h 34mAmerican Airlines
Tue 3/222:00JNB - DSM
2 stops33h 08mAmerican Airlines
Deal found 12/12R20 823
Sat 24/117:00DSM - JNB
2 stops30h 35mAmerican Airlines
Sat 31/119:35JNB - DSM
2 stops33h 29mAmerican Airlines
Deal found 11/12R20 924
Sun 25/116:46DSM - JNB
2 stops33h 39mBritish Airways
Sun 1/222:00JNB - DSM
2 stops33h 08mBritish Airways
Deal found 11/12R21 008
Wed 15/414:38DSM - JNB
2 stops33h 22mAmerican Airlines
Sun 26/421:15JNB - DSM
2 stops27h 49mAmerican Airlines
Deal found 12/12R21 244

Find flights from Des Moines within your budget

 
Find flights departing from Des Moines that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 13 December 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 27/1

17:01-7:35

2 stops30h 34m

Johannesburg OR Tambo

Tue 3/2

22:00-23:23

2 stops33h 23m

R20 418

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 26/1

16:00-7:35

2 stops31h 35m

Johannesburg OR Tambo

Mon 2/2

22:00-23:08

2 stops33h 08m

R20 823

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 27/1

16:00-7:35

2 stops31h 35m

Johannesburg OR Tambo

Tue 3/2

22:00-23:23

2 stops33h 23m

R20 823

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 25/1

16:00-10:25

2 stops34h 25m

Johannesburg OR Tambo

Sun 1/2

22:00-21:04

2 stops31h 04m

R20 856

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sat 24/1

17:00-7:35

2 stops30h 35m

Johannesburg OR Tambo

Sat 31/1

19:35-21:04

2 stops33h 29m

R20 924

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 15/4

14:38-7:00

2 stops33h 22m

Johannesburg OR Tambo

Sun 26/4

21:15-18:04

2 stops27h 49m

R21 244

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 26/1

11:42-10:25

2 stops38h 43m

Johannesburg OR Tambo

Mon 2/2

19:35-21:04

2 stops33h 29m

R22 779

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 25/1

17:01-7:35

2 stops54h 34m

Johannesburg OR Tambo

Sun 1/2

22:00-16:24

2 stops50h 24m

R23 605

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 27/1

17:01-7:35

2 stops30h 34m

Johannesburg OR Tambo

Tue 3/2

22:00-16:24

2 stops50h 24m

R24 296

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 9/1

20:17-10:50

3 stops54h 33m

R13 269

Flights are sorted by cheapest return flights first.

Deals found on 10/12

Showing 1-10 of 20 results
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Best time to book a flight from Des Moines

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Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines

Get recent, data-driven insights about flights from Des Moines including ideal travel times, pricing trends, and more.

What are popular destinations to fly to from Des Moines?

From Des Moines you can expect to find greater availability for the following destinations: Chicago (398 flights per day), Detroit (138 flights per day) and Atlanta (124 flights per day).

Denver Intl
Denver Intl
From R1 760

What is the cheapest place to fly to from Des Moines?

The cheapest city to fly to from Des Moines is Denver Intl, with prices starting at R1 760. Explore other affordable destinations below.

Denver Intl
Denver Intl
From R1 760

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Related info for your journey

Access useful and relevant information related to your journey from Des Moines. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 13 December 2025.

  • What are the most popular destinations to fly to from Des Moines?

    The most selected flight destinations from Des Moines for the current month are Denver, Hyderabad, Dallas/Fort Worth Airport. While Denver, Cancún, Nashville are the top choices made by travellers year-round.

  • What is the cheapest flight from Des Moines to anywhere?

    Users have flown out of Des Moines for as low as R1 760 to Denver (prices may vary depending on the airline and departure time). On average, users have booked flights for R1 760 to fly from Des Moines.

  • How does Cheapflights help users find flights from Des Moines?

    Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Des Moines?

    Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

  • Can Cheapflights find flights from Des Moines with no change fees?

    Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

  • Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

    Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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How does Cheapflights help users find flights from Des Moines?

Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines?

Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Des Moines with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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