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R2 205+ Cheap flights from Des Moines

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — JNB
Oct 14 — Oct 211
1 adult
1 adult, Economy

What to know about flights from Des Moines

Discover essential information about flights departing from Des Moines, including flight schedules, destinations, airlines operating at the Des Moines airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 14 September 2025.

Good round-trip deal

R5 963 or less
Price to beat on a round-trip flight from Des Moines.
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Cheapest flights from Des Moines
Explore the most affordable flight options available from Des Moines. Find the lowest fares based on data from user searches, with prices last updated on 14 September 2025.

Mon 27/1018:07DSM - JNB
2 stops33h 18mAmerican Airlines
Mon 3/1119:35JNB - DSM
2 stops34h 33mAmerican Airlines
Deal found 11/9R18 912
Thu 5/317:59DSM - JNB
2 stops32h 26mAmerican Airlines
Mon 9/319:35JNB - DSM
2 stops33h 57mAmerican Airlines
Deal found 11/9R21 829
Mon 27/105:47DSM - JNB
1 stop30h 13mDelta
Mon 3/1123:59JNB - DSM
2 stops28h 36mDelta
Deal found 11/9R24 625
Mon 27/108:30DSM - JNB
3 stops40h 50mMultiple Airlines
Mon 3/1113:45JNB - DSM
2 stops36h 25mMultiple Airlines
Deal found 11/9R27 838
Mon 6/1019:31DSM - JNB
2 stops31h 04mQatar Airways
Fri 10/1013:55JNB - DSM
2 stops32h 08mQatar Airways
Deal found 12/9R28 011
Mon 27/1013:05DSM - JNB
3 stops37h 25mAir Canada
Mon 3/1120:15JNB - DSM
3 stops33h 17mAir Canada
Deal found 11/9R28 515
Sun 28/1211:35DSM - JNB
2 stops37h 55mLufthansa
Thu 8/110:10JNB - DSM
2 stops43h 40mLufthansa
Deal found 13/9R29 244
Mon 6/108:30DSM - JNB
3 stops39h 40mMultiple Airlines
Fri 10/1013:55JNB - DSM
2 stops34h 47mMultiple Airlines
Deal found 12/9R30 252
Sun 28/1218:37DSM - JNB
1 stop40h 23mDelta
Thu 8/123:59JNB - DSM
2 stops42h 23mDelta
Deal found 13/9R31 450

Find flights from Des Moines within your budget

 
Find flights departing from Des Moines that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 14 September 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 27/10

18:07-7:35

2 stops30h 28m

Johannesburg OR Tambo

Mon 3/11

19:35-22:08

2 stops34h 33m

R18 964

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 5/3

17:59-10:25

2 stops32h 26m

Johannesburg OR Tambo

Mon 9/3

19:35-22:32

2 stops33h 57m

R21 829

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 27/10

8:30-8:20

3 stops40h 50m

Johannesburg OR Tambo

Mon 3/11

13:45-18:10

2 stops36h 25m

R27 838

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 6/10

19:31-9:35

2 stops31h 04m

Johannesburg OR Tambo

Fri 10/10

13:55-15:03

2 stops32h 08m

R28 011

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 27/10

13:05-9:30

3 stops37h 25m

Johannesburg OR Tambo

Mon 3/11

20:15-21:32

3 stops33h 17m

R28 515

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 28/12

11:35-9:30

2 stops37h 55m

Johannesburg OR Tambo

Thu 8/1

10:10-21:50

2 stops43h 40m

R29 244

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 6/10

8:30-7:10

3 stops39h 40m

Johannesburg OR Tambo

Fri 10/10

13:55-17:42

2 stops34h 47m

R30 252

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 28/12

18:37-19:00

1 stop40h 23m

Johannesburg OR Tambo

Thu 8/1

23:59-10:22

2 stops42h 23m

R31 450

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 6/10

10:50-19:40

1 stop25h 50m

Johannesburg OR Tambo

Fri 10/10

20:40-22:30

2 stops32h 50m

R33 239

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sat 13/12

18:50-9:30

2 stops54h 40m

Johannesburg OR Tambo

Sun 4/1

19:45-10:55

2 stops47h 10m

R47 809

Flights are sorted by cheapest return flights first.

Deals found on 12/9

Showing 1-10 of 14 results
1
2

Best time to book a flight from Des Moines

Have a flexible travel schedule? Discover the best time to fly from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines

Get recent, data-driven insights about flights from Des Moines including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines?

Currently, January is the cheapest month in which you can book a flight from Des Moines (average of R19 658). Flying from Des Moines in October will prove the most costly (average of R32 683). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Des Moines?

When flying from Des Moines check dates and pricing for the following: British Airways. As it departs for the following popular destinations: Johannesburg.

British Airways
British Airways
From R1 396

What are popular destinations to fly to from Des Moines?

From Des Moines you can expect to find greater availability for the following destinations: Chicago (514 flights per day), Detroit (146 flights per day) and Atlanta (137 flights per day).

Chicago
Chicago
From R279
Minneapolis St Paul
Minneapolis St Paul
From R1 817

What is the cheapest place to fly to from Des Moines?

The cheapest city to fly to from Des Moines is Chicago, with prices starting at R4 845. Explore other affordable destinations below.

Chicago
Chicago
From R279
Minneapolis St Paul
Minneapolis St Paul
From R1 817

Airline reviews for flights from Des Moines

Get insights into the airlines that provide service from Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Des Moines. In the last 7 days, Cheapflights users made a total of 594 507 searches.
Get a feel of what it's like to fly with British Airways from Des Moines by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
British Airways
6,7
Okay
7 361 reviews
Check prices

Crew

7,6

Entertainment

6,4

Food

6,3

Comfort

6,7

Boarding

6,9

Overall

6,7

Reviews

1 / 20
8,0
Excellent

Anonymous,Aug 2025

IAD - LHR

The plane had to load and unload passengers not through a jet way but out on the tarmac at Heathrow. The steps were steep. We weren't expecting to have to carry our luggage up and down stairs.
British Airways
6,7
Okay
7 361 reviews
British Airways
6,7
Okay
7 361 reviews
Check prices

Crew

7,6

Entertainment

6,4

Food

6,3

Comfort

6,7

Boarding

6,9

Overall

6,7

Reviews

1 / 20
8,0
Excellent

Anonymous,Aug 2025

IAD - LHR

The plane had to load and unload passengers not through a jet way but out on the tarmac at Heathrow. The steps were steep. We weren't expecting to have to carry our luggage up and down stairs.

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Related info for your journey

Access useful and relevant information related to your journey from Des Moines. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 14 September 2025.

  • What are the most popular destinations to fly to from Des Moines?

    The most selected flight destinations from Des Moines for the current month are Denver, Boston, Nashville. While Denver, Cancún, Nashville are the top choices made by travellers year-round.

  • What is the cheapest flight from Des Moines to anywhere?

    Users have flown out of Des Moines for as low as R4 845 to Chicago O'Hare Intl Airport (prices may vary depending on the airline and departure time). On average, users have booked flights for R29 242 to fly from Des Moines.

  • What is the cheapest month to fly from Des Moines?

    January is currently the cheapest month to fly from Des Moines. At this moment in time October is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • How does Cheapflights help users find flights from Des Moines?

    Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Des Moines?

    Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

  • Can Cheapflights find flights from Des Moines with no change fees?

    Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

  • Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

    Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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How does Cheapflights help users find flights from Des Moines?

Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines?

Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Des Moines with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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