R2 678+ Cheap flights from Des Moines

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — JNB
Apr 12 — Apr 191
1 adult
1 adult, Economy, 0 bags

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Cheapest flights from Des Moines
Explore the most affordable flight options available from Des Moines. Find the lowest fares based on data from user searches, with prices last updated on 13 March 2026.

Tue 5/512:00
DSM
-
JNB
2 stops37h 50m
Qatar Airways
Tue 2/614:45
JNB
-
DSM
2 stops35h 47m
Qatar Airways
Deal found 13/3R20 393
Fri 24/411:09
DSM
-
JNB
2 stops38h 41m
Qatar Airways
Fri 1/514:45
JNB
-
DSM
2 stops40h 04m
Qatar Airways
Deal found 10/3R20 999
Sun 26/411:09
DSM
-
JNB
2 stops38h 41m
Qatar Airways
Sun 3/520:40
JNB
-
DSM
2 stops29h 53m
Qatar Airways
Deal found 12/3R21 016
Thu 23/411:09
DSM
-
JNB
2 stops38h 41m
Qatar Airways
Thu 30/414:45
JNB
-
DSM
2 stops40h 04m
Qatar Airways
Deal found 11/3R21 033
Sun 5/413:52
DSM
-
JNB
2 stops59h 28m
Etihad Airways
Sun 12/49:50
JNB
-
DSM
2 stops37h 41m
Etihad Airways
Deal found 10/3R21 202

Find flights from Des Moines within your budget

 
Find flights departing from Des Moines that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 13 March 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 5/5

12:00-8:50

2 stops37h 50m

Johannesburg OR Tambo

Tue 2/6

14:45-19:32

2 stops35h 47m

R20 393

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 26/4

11:09-8:50

2 stops38h 41m

Johannesburg OR Tambo

Sun 3/5

14:45-19:33

2 stops35h 48m

R21 185

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 8/5

12:00-8:50

2 stops37h 50m

Johannesburg OR Tambo

Tue 12/5

14:45-23:49

2 stops40h 04m

R24 671
Fastest return journey

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 23/4

18:31-19:40

1 stop18h 09m

Johannesburg OR Tambo

Thu 30/4

20:25-17:45

2 stops28h 20m

R29 049

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 23/4

14:44-21:55

2 stops24h 11m

Johannesburg OR Tambo

Thu 30/4

23:15-17:02

2 stops48h 47m

R29 504

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 23/4

18:31-19:40

1 stop18h 09m

Johannesburg OR Tambo

Thu 30/4

18:00-17:45

2 stops30h 45m

R29 588

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 24/4

18:31-19:40

1 stop18h 09m

Johannesburg OR Tambo

Fri 1/5

20:25-22:34

2 stops33h 09m

R29 756

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 27/4

11:51-19:40

1 stop24h 49m

Johannesburg OR Tambo

Mon 4/5

20:25-22:34

2 stops33h 09m

R29 773
Cheapest one-way

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 29/7

11:04-19:40

1 stop25h 36m

R20 966

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 29/7

14:15-19:40

1 stop22h 25m

R20 966

Flights are sorted by cheapest return flights first.

Deals found on 10/3

Showing 1-10 of 14 resultsSorted by cheapest first
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Estimated return price
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Travel insights for flights from Des Moines

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Related info for your journey

Access useful and relevant information related to your journey from Des Moines. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 13 March 2026.

  • What are the most popular destinations to fly to from Des Moines?

    The most selected flight destinations from Des Moines for the current month are Las Vegas, Denver, Cancún. While Las Vegas, Denver, Cancún are the top choices made by travellers year-round.

  • How does Cheapflights help users find flights from Des Moines?

    Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Des Moines?

    Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

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    Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

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Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines?

Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Des Moines with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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