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R2 720+ Cheap flights from Des Moines

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — JNB
Nov 12 — Nov 191
1 adult
1 adult, Economy

What to know about flights from Des Moines

Discover essential information about flights departing from Des Moines, including flight schedules, destinations, airlines operating at the Des Moines airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 13 October 2025.

Good round-trip deal

R23 275 or less
Price to beat on a round-trip flight from Des Moines.
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Cheapest flights from Des Moines
Explore the most affordable flight options available from Des Moines. Find the lowest fares based on data from user searches, with prices last updated on 13 October 2025.

Thu 27/116:39DSM - JNB
2 stops40h 56mAmerican Airlines
Thu 4/1222:00JNB - DSM
2 stops33h 45mAmerican Airlines
Deal found 13/10R21 048
Tue 25/1114:15DSM - JNB
2 stops33h 20mAmerican Airlines
Tue 2/1222:00JNB - DSM
2 stops33h 48mAmerican Airlines
Deal found 11/10R21 256
Thu 5/316:27DSM - JNB
2 stops31h 08mAmerican Airlines
Mon 9/319:35JNB - DSM
2 stops33h 17mAmerican Airlines
Deal found 12/10R21 412
Wed 26/1116:03DSM - JNB
2 stops34h 22mAmerican Airlines
Wed 3/1222:00JNB - DSM
2 stops32h 29mAmerican Airlines
Deal found 12/10R21 447
Tue 25/1115:31DSM - JNB
2 stops32h 04mBritish Airways
Tue 2/1222:00JNB - DSM
2 stops28h 35mBritish Airways
Deal found 11/10R21 464
Wed 26/1116:03DSM - JNB
2 stops34h 22mBritish Airways
Wed 3/1222:00JNB - DSM
2 stops32h 29mBritish Airways
Deal found 12/10R21 533
Sun 5/418:20DSM - JNB
2 stops29h 40mAmerican Airlines
Sun 12/421:15JNB - DSM
2 stops27h 49mAmerican Airlines
Deal found 11/10R24 011

Find flights from Des Moines within your budget

 
Find flights departing from Des Moines that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 13 October 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 27/11

6:39-7:35

2 stops40h 56m

Johannesburg OR Tambo

Thu 4/12

22:00-23:45

2 stops33h 45m

R21 048

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 5/3

17:59-7:35

2 stops29h 36m

Johannesburg OR Tambo

Mon 9/3

19:35-22:32

2 stops33h 57m

R21 412

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 26/11

18:56-10:25

2 stops31h 29m

Johannesburg OR Tambo

Wed 3/12

19:35-23:52

2 stops36h 17m

R23 907

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 5/4

14:48-7:00

2 stops33h 12m

Johannesburg OR Tambo

Sun 12/4

21:15-18:04

2 stops27h 49m

R24 877

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 5/3

5:45-19:00

1 stop29h 15m

Johannesburg OR Tambo

Mon 9/3

23:59-20:53

2 stops27h 54m

R26 557

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 27/11

5:00-8:40

2 stops43h 40m

Johannesburg OR Tambo

Thu 4/12

13:45-14:51

2 stops33h 06m

R26 592

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 17/2

16:27-10:25

2 stops33h 58m

R67 008

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 17/2

16:27-10:25

2 stops33h 58m

R67 008

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 17/2

18:45-7:05

2 stops28h 20m

R72 638

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Tue 17/2

11:30-9:30

3 stops38h 00m

R78 736

Flights are sorted by cheapest return flights first.

Deals found on 13/10

Showing 1-10 of 11 results
1
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Best time to book a flight from Des Moines

Have a flexible travel schedule? Discover the best time to fly from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines

Get recent, data-driven insights about flights from Des Moines including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines?

Currently, January is the cheapest month in which you can book a flight from Des Moines (average of R21 118). Flying from Des Moines in October will prove the most costly (average of R32 603). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Des Moines?

When flying from Des Moines check dates and pricing for the following: British Airways. As it departs for the following popular destinations: Johannesburg.

British Airways
British Airways
From R24 180

What are popular destinations to fly to from Des Moines?

From Des Moines you can expect to find greater availability for the following destinations: Chicago (598 flights per day), Atlanta (154 flights per day) and Detroit (148 flights per day).

Chicago
Chicago
From R23 275
Minneapolis St Paul
Minneapolis St Paul
From R31 485

What is the cheapest place to fly to from Des Moines?

The cheapest city to fly to from Des Moines is Chicago, with prices starting at R23 275. Explore other affordable destinations below.

Chicago
Chicago
From R23 275
Minneapolis St Paul
Minneapolis St Paul
From R31 485

Airline reviews for flights from Des Moines

Get insights into the airlines that provide service from Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Des Moines. In the last 7 days, Cheapflights users made a total of 594 507 searches.
Get a feel of what it's like to fly with British Airways from Des Moines by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
British Airways
6,7
Okay
7 453 reviews
Check prices

Overall

6,7

Boarding

6,9

Food

6,3

Comfort

6,7

Crew

7,6

Entertainment

6,4

Reviews

1 / 20
8,0
Excellent

Anonymous,Aug 2025

IAD - LHR

The plane had to load and unload passengers not through a jet way but out on the tarmac at Heathrow. The steps were steep. We weren't expecting to have to carry our luggage up and down stairs.
British Airways
6,7
Okay
7 453 reviews
British Airways
6,7
Okay
7 453 reviews
Check prices

Overall

6,7

Boarding

6,9

Food

6,3

Comfort

6,7

Crew

7,6

Entertainment

6,4

Reviews

1 / 20
8,0
Excellent

Anonymous,Aug 2025

IAD - LHR

The plane had to load and unload passengers not through a jet way but out on the tarmac at Heathrow. The steps were steep. We weren't expecting to have to carry our luggage up and down stairs.

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Related info for your journey

Access useful and relevant information related to your journey from Des Moines. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 13 October 2025.

  • What are the most popular destinations to fly to from Des Moines?

    The most selected flight destinations from Des Moines for the current month are Denver, Nashville, Boston. While Denver, Cancún, Nashville are the top choices made by travellers year-round.

  • What is the cheapest flight from Des Moines to anywhere?

    Users have flown out of Des Moines for as low as R23 275 to Chicago O'Hare Intl Airport (prices may vary depending on the airline and departure time). On average, users have booked flights for R27 606 to fly from Des Moines.

  • What is the cheapest month to fly from Des Moines?

    January is currently the cheapest month to fly from Des Moines. At this moment in time October is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • How does Cheapflights help users find flights from Des Moines?

    Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Des Moines?

    Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

  • Can Cheapflights find flights from Des Moines with no change fees?

    Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

  • Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

    Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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How does Cheapflights help users find flights from Des Moines?

Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines?

Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Des Moines with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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