R2 860+ Cheap flights from Des Moines

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — JNB
Mar 8 — Mar 151
1 adult
1 adult, Economy, 0 bags

What to know about flights from Des Moines

Discover essential information about flights departing from Des Moines, including flight schedules, destinations, airlines operating at the Des Moines airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 6 February 2026.

Good one-way deal

R1 687 or less
Price to beat on a one-way flight from Des Moines.
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Cheapest flights from Des Moines
Explore the most affordable flight options available from Des Moines. Find the lowest fares based on data from user searches, with prices last updated on 6 February 2026.

Wed 11/313:37
DSM
-
JNB
2 stops34h 58m
American Airlines
Tue 24/322:00
JNB
-
DSM
2 stops30h 59m
American Airlines
Deal found 6/2R20 443
Sun 5/419:27
DSM
-
JNB
2 stops60h 53m
Qatar Airways
Sun 12/412:40
JNB
-
DSM
2 stops42h 19m
Qatar Airways
Deal found 3/2R22 333
Mon 23/315:26
DSM
-
JNB
2 stops33h 09m
American Airlines
Mon 30/321:15
JNB
-
DSM
2 stops31h 04m
American Airlines
Deal found 5/2R22 689
Sun 21/618:29
DSM
-
JNB
2 stops31h 56m
American Airlines
Sun 12/721:15
JNB
-
DSM
2 stops29h 13m
American Airlines
Deal found 4/2R22 883
Fri 20/311:17
DSM
-
JNB
2 stops33h 38m
Qatar Airways
Fri 27/312:45
JNB
-
DSM
2 stops33h 11m
Qatar Airways
Deal found 3/2R23 836
Mon 23/313:37
DSM
-
JNB
2 stops37h 48m
British Airways
Mon 30/321:15
JNB
-
DSM
2 stops32h 20m
British Airways
Deal found 6/2R24 030
Mon 23/310:51
DSM
-
JNB
2 stops28h 14m
KLM
Mon 30/323:15
JNB
-
DSM
2 stops28h 55m
KLM
Deal found 6/2R24 353
Sat 21/319:27
DSM
-
JNB
2 stops37h 08m
Qatar Airways
Sat 28/312:45
JNB
-
DSM
2 stops37h 15m
Qatar Airways
Deal found 3/2R24 386
Thu 5/35:05
DSM
-
JNB
2 stops38h 50m
Qatar Airways
Mon 9/312:45
JNB
-
DSM
2 stops35h 53m
Qatar Airways
Deal found 3/2R24 547

Find flights from Des Moines within your budget

 
Find flights departing from Des Moines that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 6 February 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 5/4

19:27-15:20

2 stops60h 53m

Johannesburg OR Tambo

Sun 12/4

12:40-23:59

2 stops42h 19m

R22 333

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 21/6

18:29-7:00

2 stops29h 31m

Johannesburg OR Tambo

Sun 12/7

19:25-19:28

2 stops31h 03m

R22 899

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 20/3

11:17-3:55

2 stops33h 38m

Johannesburg OR Tambo

Fri 27/3

12:45-14:56

2 stops33h 11m

R23 836

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 23/3

10:51-22:05

2 stops28h 14m

Johannesburg OR Tambo

Mon 30/3

23:15-21:10

2 stops28h 55m

R24 353

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 5/3

5:05-3:55

2 stops38h 50m

Johannesburg OR Tambo

Mon 9/3

12:45-17:38

2 stops35h 53m

R24 547

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 23/3

11:33-19:00

1 stop24h 27m

Johannesburg OR Tambo

Mon 30/3

23:15-21:10

2 stops28h 55m

R24 838

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sat 21/3

13:52-7:35

2 stops34h 43m

Johannesburg OR Tambo

Sat 28/3

22:00-20:00

2 stops29h 00m

R25 339

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 27/2

11:17-3:55

2 stops32h 38m

R11 781

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 20/3

19:37-15:35

2 stops36h 58m

R12 169

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 27/2

6:00-8:20

3 stops42h 20m

R15 837

Flights are sorted by cheapest return flights first.

Deals found on 4/2

Showing 1-10 of 17 results
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Best time to book a flight from Des Moines

Have a flexible travel schedule? Discover the best time to fly from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines

Get recent, data-driven insights about flights from Des Moines including ideal travel times, pricing trends, and more.

What are popular destinations to fly to from Des Moines?

From Des Moines you can expect to find greater availability for the following destinations: Chicago (464 flights per day), Detroit (122 flights per day) and Dallas (114 flights per day).

Denver Intl
Denver Intl
From R1 687

What is the cheapest place to fly to from Des Moines?

The cheapest city to fly to from Des Moines is Denver Intl, with prices starting at R1 687. Explore other affordable destinations below.

Denver Intl
Denver Intl
From R1 687

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Direct flights from Iowa

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Direct flights from Cedar Rapids

Related info for your journey

Access useful and relevant information related to your journey from Des Moines. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 6 February 2026.

  • What are the most popular destinations to fly to from Des Moines?

    The most selected flight destinations from Des Moines for the current month are Denver, Cancún, Fort Lauderdale. While Denver, Cancún, Nashville are the top choices made by travellers year-round.

  • What is the cheapest flight from Des Moines to anywhere?

    Users have flown out of Des Moines for as low as R1 687 to Denver (prices may vary depending on the airline and departure time). On average, users have booked flights for R1 687 to fly from Des Moines.

  • How does Cheapflights help users find flights from Des Moines?

    Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Des Moines?

    Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

  • Can Cheapflights find flights from Des Moines with no change fees?

    Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

  • Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

    Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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How does Cheapflights help users find flights from Des Moines?

Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines?

Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Des Moines with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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