R3 647+ Cheap flights from Des Moines

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 22/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
DSM — JNB
Aug 26 — Sep 21
1 adult
1 adult, Economy, 0 bags

Find flights from Des Moines within your budget

 
Find flights departing from Des Moines that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 27 July 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Thu 10/9

14:44-8:15

2 stops34h 31m

Johannesburg OR Tambo

Thu 17/9

9:45-0:04

2 stops45h 19m

R21 817

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sat 5/9

13:55-8:20

2 stops35h 25m

Johannesburg OR Tambo

Sat 12/9

9:45-0:04

2 stops45h 19m

R22 069

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 11/9

14:29-4:00

2 stops30h 31m

Johannesburg OR Tambo

Sun 20/9

20:55-19:21

2 stops29h 26m

R25 397

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 15/11

6:05-20:10

2 stops30h 05m

Johannesburg OR Tambo

Sun 22/11

14:30-14:19

3 stops31h 49m

R28 389

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 11/9

15:22-20:10

2 stops45h 48m

Johannesburg OR Tambo

Sun 20/9

14:30-21:28

3 stops37h 58m

R28 876

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Wed 9/9

11:32-20:10

2 stops49h 38m

Johannesburg OR Tambo

Wed 16/9

14:30-21:33

3 stops38h 03m

R29 347

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 7/9

11:28-19:40

1 stop25h 12m

Johannesburg OR Tambo

Wed 23/9

21:55-18:09

1 stop27h 14m

R31 297
Fastest return journey

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Fri 11/9

11:31-19:40

1 stop25h 09m

Johannesburg OR Tambo

Sun 20/9

21:55-13:49

1 stop22h 54m

R31 347

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Mon 7/9

11:28-19:40

1 stop25h 12m

Johannesburg OR Tambo

Mon 14/9

21:55-18:09

1 stop27h 14m

R32 608
Cheapest one-way

Des MoinesJohannesburg

DSM - JNB

DSMJNB

Des Moines

Sun 6/9

10:30-7:55

2 stops38h 25m

R19 363

Flights are sorted by cheapest return flights first.

Deals found on 23/7

Showing 1-10 of 12 resultsSorted by cheapest first
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Best time to book a flight from Des Moines

Have a flexible travel schedule? Discover the best time to fly from Des Moines with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines

Get recent, data-driven insights about flights from Des Moines including ideal travel times, pricing trends, and more.

What are popular destinations to fly to from Des Moines?

From Des Moines you can expect to find greater availability for the following destinations: Chicago (484 flights per day), Detroit (168 flights per day) and Atlanta (153 flights per day).

Chicago
Chicago
From R8 486

What is the cheapest place to fly to from Des Moines?

The cheapest city to fly to from Des Moines is Chicago, with prices starting at R8 486. Explore other affordable destinations below.

Chicago
Chicago
From R8 486

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Direct flights from Iowa

Book a direct flight from one of these other cities located in Iowa.
Direct flights from Cedar Rapids

Related info for your journey

Access useful and relevant information related to your journey from Des Moines. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 27 July 2026.

  • What are the most popular destinations to fly to from Des Moines?

    The most selected flight destinations from Des Moines for the current month are Denver, Las Vegas, Los Angeles. While Las Vegas, Denver, Los Angeles are the top choices made by travellers year-round.

  • What is the cheapest flight from Des Moines to anywhere?

    Users have flown out of Des Moines for as low as R8 486 to Chicago O'Hare Intl Airport (prices may vary depending on the airline and departure time). On average, users have booked flights for R8 486 to fly from Des Moines.

  • How does Cheapflights help users find flights from Des Moines?

    Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Des Moines?

    Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

  • Can Cheapflights find flights from Des Moines with no change fees?

    Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

  • Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

    Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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How does Cheapflights help users find flights from Des Moines?

Cheapflights helps you search for flights from Des Moines via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Des Moines?

Millions of users choose and trust Cheapflights to book the best flight deals from Des Moines for free. We help you search and compare prices from hundreds of airlines for the right flight just for you.

Can Cheapflights find flights from Des Moines with no change fees?

Users can book flights with no change fees policies with our dedicated filters. Book flights from Des Moines flexibly with Cheapflights today.

Can Cheapflights notify me if prices for flights from Des Moines become cheaper?

Of course! You can now track prices for flights from Des Moines and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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