This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Dec 3 — Dec 101
Return
1 adult
Economy
Return
1 adult, Economy, 0 bags
Find direct flights from Panama City within your budget
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 7 457 451 searches. This data was last updated on 3 November 2026.
Fly to
Route
Depart
Return
Price
Cheapest return flight
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Tue 15/12
9:19-12:10
Nonstop3h 51m
Mexico City Benito Juarez
Wed 31/12
0:00-1:00
Nonstop0h 00m
R3 410
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Wed 9/12
11:44-14:30
Nonstop3h 46m
Mexico City Benito Juarez
Thu 7/1
9:10-13:54
Nonstop3h 44m
R6 421
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Thu 17/12
19:32-22:25
Nonstop3h 53m
Mexico City Benito Juarez
Tue 22/12
9:10-14:01
Nonstop3h 51m
R6 421
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Wed 23/12
21:26-0:15
Nonstop3h 49m
Mexico City Benito Juarez
Thu 7/1
13:10-17:58
Nonstop3h 48m
R6 604
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Sun 24/1
11:44-14:30
Nonstop3h 46m
Mexico City Benito Juarez
Sun 7/2
9:10-13:58
Nonstop3h 48m
R6 604
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Fri 18/12
11:44-14:30
Nonstop3h 46m
Mexico City Benito Juarez
Fri 25/12
9:10-14:01
Nonstop3h 51m
R6 604
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Wed 16/12
21:26-0:15
Nonstop3h 49m
Mexico City Benito Juarez
Tue 5/1
15:30-20:17
Nonstop3h 47m
R6 704
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Fri 12/2
19:25-22:25
Nonstop4h 00m
Mexico City Benito Juarez
Thu 18/2
1:20-5:57
Nonstop3h 37m
R6 771
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Sat 6/2
11:44-14:30
Nonstop3h 46m
Mexico City Benito Juarez
Fri 19/2
3:25-8:02
Nonstop3h 37m
R6 771
Panama CityMexico City
PTY Panama City Tocumen Intl - MEX Mexico City Benito Juarez
PTYMEX
Panama City Tocumen Intl
Fri 27/11
16:29-19:20
Nonstop3h 51m
Mexico City Benito Juarez
Mon 30/11
5:55-10:47
Nonstop3h 52m
R7 054
Flights are sorted by cheapest return flights first.
Deals found on 3/11
Showing 1-10 of 33 resultsSorted by cheapest first
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Best time to book a flight from Panama City
Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
PTY-JNB
PTY-MEX
PTY-GRU
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 3 November 2026.
Where can you fly direct from Panama City?
Currently, the most popular direct flight destination from Panama City is Sao Paulo Guarulhos Intl Airport.
What is the best time of year to fly direct from Panama City?
If you're seeking the lowest price on a direct flight from Panama City, March is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, June offers travelers the most options.
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