R9 463+ Cheap flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 25/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Apr 27 — May 41
1 adult
1 adult, Economy, 0 bags

Find flights from Panama City within your budget

 
Find flights departing from Panama City that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 28 March 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 15/4

15:30-15:20

2 stops40h 50m

Cape Town Intl

Sun 17/5

20:00-18:37

2 stops53h 37m

R17 060

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Thu 16/4

19:25-15:20

2 stops60h 55m

Cape Town Intl

Thu 14/5

17:55-6:13

2 stops43h 18m

R18 018

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 22/4

18:02-15:20

2 stops38h 18m

Cape Town Intl

Sun 26/4

17:55-20:41

2 stops33h 46m

R18 172

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Thu 16/4

9:13-15:20

1 stop23h 07m

Cape Town Intl

Tue 12/5

17:55-6:13

2 stops43h 18m

R18 942

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 13/5

8:11-8:35

2 stops41h 24m

Johannesburg OR Tambo

Sun 17/5

19:00-6:13

2 stops42h 13m

R19 045

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 11/5

22:20-11:50

1 stop30h 30m

Cape Town Intl

Sun 17/5

16:35-18:30

2 stops32h 55m

R19 507

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 9/5

22:20-11:50

1 stop30h 30m

Cape Town Intl

Sun 24/5

16:35-20:25

1 stop34h 50m

R20 739

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 17/5

20:05-10:30

1 stop31h 25m

Johannesburg OR Tambo

Sun 24/5

18:00-18:30

2 stops31h 30m

R22 245

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Thu 14/5

21:44-20:55

2 stops40h 11m

Cape Town Intl

Tue 19/5

22:25-6:33

2 stops39h 08m

R22 655

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 9/5

21:41-21:25

2 stops40h 44m

Cape Town Intl

Sun 24/5

18:25-16:50

2 stops29h 25m

R23 015

Flights are sorted by cheapest return flights first.

Deals found on 24/3

Showing 1-10 of 20 resultsSorted by cheapest first
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City

Get recent, data-driven insights about flights from Panama City including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama City?

Currently, September is the cheapest month in which you can book a flight from Panama City (average of R13 706). Flying from Panama City in December will prove the most costly (average of R39 356). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

What are popular destinations to fly to from Panama City?

From Panama City you can expect to find greater availability for the following destinations: Sao Paulo (164 flights per day), San José (95 flights per day) and Miami (91 flights per day).

Bogotá El Dorado
Bogotá El Dorado
From R1 318
Madrid Barajas
Madrid Barajas
From R17 335

What is the cheapest place to fly to from Panama City?

The cheapest city to fly to from Panama City is Bogotá El Dorado, with prices starting at R1 318. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 318
Madrid Barajas
Madrid Barajas
From R17 335

Browse thousands of different options on Cheapflights for your next trip

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Direct flights from Panama

Book a direct flight from one of these other cities located in Panama.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 28 March 2026.

  • What are the most popular destinations to fly to from Panama City?

    The most selected flight destinations from Panama City for the current month are Bogotá, Bocas del Toro, David. While Bogotá, Cancún, Cartagena are the top choices made by travellers year-round.

  • What is the cheapest flight from Panama City to anywhere?

    Users have flown out of Panama City for as low as R17 335 to Madrid (prices may vary depending on the airline and departure time). On average, users have booked flights for R17 335 to fly from Panama City.

  • What is the cheapest month to fly from Panama City?

    September is currently the cheapest month to fly from Panama City. At this moment in time December is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • How does Cheapflights help users find flights from Panama City?

    Deals for flights from Panama City are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose to your preference, such as price, airport, cabin class, and plenty of other options.

  • Why should you use Cheapflights to find cheap flight tickets from Panama City?

    Cheapflights simply makes it quick and affordable to book flights from Panama City by bringing together all flight options from hundreds of airlines and agencies online — and we put them in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

  • Can Cheapflights find flights from Panama City with no change fees?

    Certainly. Search results for flights from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

  • Can Cheapflights notify me if prices for flights from Panama City become cheaper?

    Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and use a valid email address to enable the Price Alerts feature. That’s it!

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Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City?

Deals for flights from Panama City are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose to your preference, such as price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Panama City?

Cheapflights simply makes it quick and affordable to book flights from Panama City by bringing together all flight options from hundreds of airlines and agencies online — and we put them in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Panama City with no change fees?

Certainly. Search results for flights from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama City become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and use a valid email address to enable the Price Alerts feature. That’s it!

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