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R9 397+ Cheap flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Jan 14 — Jan 211
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama City

Discover essential information about flights departing from Panama City, including flight schedules, destinations, airlines operating at the Panama City airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 15 December 2025.

Good round-trip deal

R17 091 or less

Good one-way deal

R1 299 or less
Price to beat on a round-trip flight from Panama City Tocumen Intl.
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Price to beat on a one-way flight from Panama City Tocumen Intl.
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Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 15 December 2025.

Fri 20/218:31PTY - JNB
2 stops31h 59mLufthansa
Wed 13/519:00JNB - PTY
2 stops44h 49mLufthansa
Deal found 13/12R15 740
Sun 10/518:28PTY - CPT
2 stops32h 02mLufthansa
Sat 23/518:05CPT - PTY
2 stops45h 44mLufthansa
Deal found 12/12R15 841
Mon 9/29:11PTY - CPT
1 stop23h 59mUnited Airlines
Mon 23/220:50CPT - PTY
2 stops40h 47mUnited Airlines
Deal found 14/12R16 803
Mon 13/418:50PTY - JNB
1 stop43h 30mKLM
Mon 20/423:15JNB - PTY
1 stop24h 35mKLM
Deal found 14/12R17 123
Sun 10/518:50PTY - CPT
1 stop43h 35mKLM
Sat 23/523:15CPT - PTY
1 stop24h 35mKLM
Deal found 15/12R17 140
Tue 13/18:16PTY - CPT
2 stops40h 24mUnited Airlines
Tue 20/120:50CPT - PTY
1 stop23h 41mUnited Airlines
Deal found 14/12R17 410
Sun 10/522:10PTY - CPT
2 stops40h 15mMultiple Airlines
Sat 23/523:15CPT - PTY
1 stop24h 35mMultiple Airlines
Deal found 12/12R17 460
Tue 19/59:45PTY - CPT
2 stops40h 45mUnited Airlines
Tue 26/520:00CPT - PTY
2 stops28h 10mUnited Airlines
Deal found 13/12R17 764
Wed 1/420:10PTY - JNB
1 stop31h 25mTurkish Airlines
Fri 3/418:00JNB - PTY
1 stop33h 20mTurkish Airlines
Deal found 13/12R18 658
Sun 10/59:13PTY - CPT
2 stops41h 17mUnited Airlines
Sat 23/518:05CPT - PTY
2 stops33h 30mUnited Airlines
Deal found 15/12R18 793
Sun 10/522:10PTY - CPT
2 stops40h 15mAir France
Sat 23/523:15CPT - PTY
2 stops27h 30mAir France
Deal found 13/12R18 878
Tue 19/520:10PTY - CPT
1 stop32h 40mTurkish Airlines
Tue 26/516:40CPT - PTY
1 stop34h 40mTurkish Airlines
Deal found 13/12R20 075

Find flights from Panama City within your budget

 
Find flights departing from Panama City that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 15 December 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 20/2

18:31-9:30

2 stops31h 59m

Johannesburg OR Tambo

Wed 13/5

19:00-8:49

2 stops44h 49m

R15 740

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

9:11-16:10

1 stop23h 59m

Cape Town Intl

Mon 23/2

20:50-6:37

2 stops40h 47m

R16 803

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

18:50-21:20

1 stop43h 30m

Johannesburg OR Tambo

Mon 20/4

23:15-16:50

1 stop24h 35m

R17 123

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 10/5

18:50-21:25

1 stop43h 35m

Cape Town Intl

Sat 23/5

23:15-16:50

1 stop24h 35m

R17 140

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 13/1

8:16-7:40

2 stops40h 24m

Cape Town Intl

Tue 20/1

20:50-13:31

1 stop23h 41m

R17 410

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 20/1

9:11-7:40

2 stops39h 29m

Cape Town Intl

Tue 27/1

20:50-20:35

1 stop30h 45m

R17 410

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 10/5

22:10-21:25

2 stops40h 15m

Cape Town Intl

Sat 23/5

23:15-16:50

1 stop24h 35m

R17 460

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 19/5

9:45-9:30

2 stops40h 45m

Cape Town Intl

Tue 26/5

20:00-17:10

2 stops28h 10m

R17 764

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 1/4

20:10-10:35

1 stop31h 25m

Johannesburg OR Tambo

Fri 3/4

18:00-20:20

1 stop33h 20m

R18 658

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 10/5

9:13-9:30

2 stops41h 17m

Cape Town Intl

Sat 23/5

18:05-20:35

2 stops33h 30m

R18 793

Flights are sorted by cheapest return flights first.

Deals found on 13/12

Showing 1-10 of 22 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City

Get recent, data-driven insights about flights from Panama City including ideal travel times, pricing trends, and more.

Which airlines fly from Panama City?

When flying from Panama City check dates and pricing for the following: United Airlines. As it departs for the following popular destinations: Johannesburg.

United Airlines
United Airlines
From R12 622

What are popular destinations to fly to from Panama City?

From Panama City you can expect to find greater availability for the following destinations: Sao Paulo (252 flights per day), San José (159 flights per day) and Miami (122 flights per day).

Bogotá El Dorado
Bogotá El Dorado
From R1 299
Madrid Barajas
Madrid Barajas
From R17 091

What is the cheapest place to fly to from Panama City?

The cheapest city to fly to from Panama City is Bogotá El Dorado, with prices starting at R1 299. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 299
Madrid Barajas
Madrid Barajas
From R17 091

Airline reviews for flights from Panama City

Get insights into the airlines that provide service from Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama City. In the last 7 days, Cheapflights users made a total of 594 507 searches.
Get a feel of what it's like to fly with United Airlines from Panama City by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7,4
Good
9 092 reviews
Check prices

Crew

8,1

Comfort

7,3

Overall

7,4

Boarding

7,7

Food

6,6

Entertainment

7,1

Reviews

1 / 20
8,0
Excellent

Anonymous,Dec 2025

AMS - EWR

It was good! The first 3/4 of the trip was uncomfortably cold. Only one option for lunch that I didn’t enjoy (vegetarian).
United Airlines
7,4
Good
9 092 reviews
United Airlines
7,4
Good
9 092 reviews
Check prices

Crew

8,1

Comfort

7,3

Overall

7,4

Boarding

7,7

Food

6,6

Entertainment

7,1

Reviews

1 / 20
8,0
Excellent

Anonymous,Dec 2025

AMS - EWR

It was good! The first 3/4 of the trip was uncomfortably cold. Only one option for lunch that I didn’t enjoy (vegetarian).

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Direct flights from Panama

Book a direct flight from one of these other cities located in Panama.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 15 December 2025.

  • What are the most popular destinations to fly to from Panama City?

    The most selected flight destinations from Panama City for the current month are Bogotá, Cali, Barranquilla. While Bogotá, Cancún, Cartagena are the top choices made by travellers year-round.

  • What is the cheapest flight from Panama City to anywhere?

    Users have flown out of Panama City for as low as R16 599 to Istanbul Airport (prices may vary depending on the airline and departure time). On average, users have booked flights for R16 845 to fly from Panama City.

  • How does Cheapflights help users find flights from Panama City?

    Deals for flights from Panama City are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose to your preference, such as price, airport, cabin class, and plenty of other options.

  • Why should you use Cheapflights to find cheap flight tickets from Panama City?

    Cheapflights simply makes it quick and affordable to book flights from Panama City by bringing together all flight options from hundreds of airlines and agencies online — and we put them in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

  • Can Cheapflights find flights from Panama City with no change fees?

    Certainly. Search results for flights from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

  • Can Cheapflights notify me if prices for flights from Panama City become cheaper?

    Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and use a valid email address to enable the Price Alerts feature. That’s it!

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Fly with Cheapflights

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How does Cheapflights help users find flights from Panama City?

Deals for flights from Panama City are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose to your preference, such as price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Panama City?

Cheapflights simply makes it quick and affordable to book flights from Panama City by bringing together all flight options from hundreds of airlines and agencies online — and we put them in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Panama City with no change fees?

Certainly. Search results for flights from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama City become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and use a valid email address to enable the Price Alerts feature. That’s it!

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