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R9 133+ Cheap flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Feb 9 — Feb 161
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama City

Discover essential information about flights departing from Panama City, including flight schedules, destinations, airlines operating at the Panama City airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 10 January 2026.

Good round-trip deal

R16 731 or less

Good one-way deal

R1 272 or less
Price to beat on a round-trip flight from Panama City Tocumen Intl.
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Price to beat on a one-way flight from Panama City Tocumen Intl.
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Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 10 January 2026.

Fri 22/518:28PTY - JNB
2 stops31h 07mLufthansa
Tue 9/619:00JNB - PTY
2 stops42h 48mLufthansa
Deal found 9/1R15 342
Fri 22/518:28PTY - CPT
2 stops32h 02mLufthansa
Tue 9/617:55CPT - PTY
2 stops43h 53mLufthansa
Deal found 9/1R15 541
Fri 30/18:55PTY - CPT
2 stops26h 05mUnited Airlines
Wed 4/220:50CPT - PTY
2 stops30h 45mUnited Airlines
Deal found 9/1R16 432
Sun 15/222:20PTY - JNB
1 stop30h 50mMultiple Airlines
Sun 15/323:59JNB - PTY
1 stop23h 31mMultiple Airlines
Deal found 9/1R16 796
Sun 15/218:45PTY - JNB
1 stop44h 20mKLM
Sun 15/323:59JNB - PTY
1 stop23h 31mKLM
Deal found 8/1R16 812
Fri 22/518:50PTY - CPT
1 stop43h 35mKLM
Mon 8/623:15CPT - PTY
1 stop24h 35mKLM
Deal found 9/1R16 829
Mon 13/421:55PTY - JNB
2 stops40h 25mKLM
Mon 20/423:15JNB - PTY
1 stop24h 35mKLM
Deal found 8/1R17 159
Mon 9/222:20PTY - JNB
1 stop30h 50mAir France
Tue 17/223:59JNB - PTY
2 stops27h 11mAir France
Deal found 9/1R17 324
Fri 22/518:50PTY - CPT
1 stop43h 35mKLM
Tue 9/623:15CPT - PTY
2 stops51h 30mKLM
Deal found 9/1R17 357
Fri 22/59:13PTY - CPT
2 stops41h 17mUnited Airlines
Sun 7/620:00CPT - PTY
1 stop24h 31mUnited Airlines
Deal found 9/1R17 407
Sun 15/222:29PTY - JNB
2 stops37h 06mUnited Airlines
Sun 15/319:45JNB - PTY
2 stops40h 48mUnited Airlines
Deal found 8/1R17 407
Sat 9/518:27PTY - CPT
2 stops39h 43mUnited Airlines
Sat 23/517:55CPT - PTY
2 stops43h 18mUnited Airlines
Deal found 9/1R17 555

Find flights from Panama City within your budget

 
Find flights departing from Panama City that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 10 January 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 22/5

18:28-9:30

2 stops32h 02m

Cape Town Intl

Tue 9/6

17:55-6:48

2 stops43h 53m

R15 541

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 22/5

18:28-9:30

2 stops32h 02m

Cape Town Intl

Sun 7/6

17:55-6:48

2 stops43h 53m

R15 541

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 30/1

8:16-18:00

2 stops26h 44m

Cape Town Intl

Wed 4/2

20:50-20:35

2 stops30h 45m

R16 432

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 15/2

22:20-12:10

1 stop30h 50m

Johannesburg OR Tambo

Sun 15/3

23:59-16:30

1 stop23h 31m

R16 796

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 15/2

18:45-22:05

1 stop44h 20m

Johannesburg OR Tambo

Sun 15/3

23:59-16:30

1 stop23h 31m

R16 812

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 22/5

18:50-21:25

1 stop43h 35m

Cape Town Intl

Tue 9/6

23:15-16:50

1 stop24h 35m

R16 829

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Thu 21/5

21:55-11:05

1 stop30h 10m

Johannesburg OR Tambo

Mon 8/6

18:00-16:50

2 stops29h 50m

R17 143

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

21:55-21:20

2 stops40h 25m

Johannesburg OR Tambo

Mon 20/4

23:15-16:50

1 stop24h 35m

R17 143

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 9/2

22:20-12:10

1 stop30h 50m

Johannesburg OR Tambo

Tue 17/2

23:59-20:10

2 stops27h 11m

R17 324

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 22/5

9:13-9:30

2 stops41h 17m

Cape Town Intl

Sun 7/6

20:00-13:31

1 stop24h 31m

R17 407

Flights are sorted by cheapest return flights first.

Deals found on 8/1

Showing 1-10 of 27 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama City

Get recent, data-driven insights about flights from Panama City including ideal travel times, pricing trends, and more.

Which airlines fly from Panama City?

When flying from Panama City check dates and pricing for the following: United Airlines. As it departs for the following popular destinations: Johannesburg.

United Airlines
United Airlines
From R12 357

What are popular destinations to fly to from Panama City?

From Panama City you can expect to find greater availability for the following destinations: Sao Paulo (280 flights per day), San José (143 flights per day) and Miami (124 flights per day).

Bogotá El Dorado
Bogotá El Dorado
From R1 272
Madrid Barajas
Madrid Barajas
From R16 731

What is the cheapest place to fly to from Panama City?

The cheapest city to fly to from Panama City is Bogotá El Dorado, with prices starting at R1 272. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 272
Madrid Barajas
Madrid Barajas
From R16 731

Airline reviews for flights from Panama City

Get insights into the airlines that provide service from Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama City. In the last 7 days, Cheapflights users made a total of 594 507 searches.
Get a feel of what it's like to fly with United Airlines from Panama City by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7,4
Good
9 145 reviews
Check prices

Boarding

7,7

Comfort

7,3

Entertainment

7,1

Crew

8,1

Food

6,6

Overall

7,4

Reviews

1 / 20
8,0
Excellent

Anonymous,Dec 2025

AMS - EWR

It was good! The first 3/4 of the trip was uncomfortably cold. Only one option for lunch that I didn’t enjoy (vegetarian).
United Airlines
7,4
Good
9 145 reviews
United Airlines
7,4
Good
9 145 reviews
Check prices

Boarding

7,7

Comfort

7,3

Entertainment

7,1

Crew

8,1

Food

6,6

Overall

7,4

Reviews

1 / 20
8,0
Excellent

Anonymous,Dec 2025

AMS - EWR

It was good! The first 3/4 of the trip was uncomfortably cold. Only one option for lunch that I didn’t enjoy (vegetarian).

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Direct flights from Panama

Book a direct flight from one of these other cities located in Panama.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 10 January 2026.

  • What are the most popular destinations to fly to from Panama City?

    The most selected flight destinations from Panama City for the current month are Bogotá, Cancún, Bocas del Toro. While Bogotá, Cancún, Cartagena are the top choices made by travellers year-round.

  • What is the cheapest flight from Panama City to anywhere?

    Users have flown out of Panama City for as low as R16 250 to Istanbul Airport (prices may vary depending on the airline and departure time). On average, users have booked flights for R16 490 to fly from Panama City.

  • How does Cheapflights help users find flights from Panama City?

    Deals for flights from Panama City are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose to your preference, such as price, airport, cabin class, and plenty of other options.

  • Why should you use Cheapflights to find cheap flight tickets from Panama City?

    Cheapflights simply makes it quick and affordable to book flights from Panama City by bringing together all flight options from hundreds of airlines and agencies online — and we put them in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

  • Can Cheapflights find flights from Panama City with no change fees?

    Certainly. Search results for flights from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

  • Can Cheapflights notify me if prices for flights from Panama City become cheaper?

    Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and use a valid email address to enable the Price Alerts feature. That’s it!

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Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama City?

Deals for flights from Panama City are sourced from 900+ travel sites when you use Cheapflights. When all flight results come back, Cheapflights lets you sort and filter flights using different criteria to choose to your preference, such as price, airport, cabin class, and plenty of other options.

Why should you use Cheapflights to find cheap flight tickets from Panama City?

Cheapflights simply makes it quick and affordable to book flights from Panama City by bringing together all flight options from hundreds of airlines and agencies online — and we put them in one place for you to choose from. Plus, Cheapflights is 100% free to use for all.

Can Cheapflights find flights from Panama City with no change fees?

Certainly. Search results for flights from Panama City shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama City become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and use a valid email address to enable the Price Alerts feature. That’s it!

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