R3 251+ Cheap flights from Knoxville

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
TYS — JNB
Nov 28 — Dec 51
1 adult
1 adult, Economy, 0 bags

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Cheapest flights from Knoxville
Explore the most affordable flight options available from Knoxville. Find the lowest fares based on data from user searches, with prices last updated on 29 October 2025.

Thu 12/318:25TYS - JNB
2 stops34h 00mAmerican Airlines
Mon 16/322:00JNB - TYS
2 stops27h 17mAmerican Airlines
Deal found 28/10R21 260
Sat 21/320:31TYS - CPT
2 stops29h 34mAmerican Airlines
Wed 25/320:35CPT - TYS
2 stops28h 42mAmerican Airlines
Deal found 26/10R23 582
Thu 1/116:12TYS - JNB
2 stops32h 23mAmerican Airlines
Fri 16/122:00JNB - TYS
2 stops30h 21mAmerican Airlines
Deal found 27/10R24 701
Fri 6/316:15TYS - CPT
2 stops32h 50mAmerican Airlines
Fri 13/320:50CPT - TYS
2 stops30h 39mAmerican Airlines
Deal found 26/10R24 873
Wed 31/1216:29TYS - JNB
2 stops32h 06mAmerican Airlines
Wed 14/122:00JNB - TYS
2 stops29h 56mAmerican Airlines
Deal found 27/10R25 045
Wed 31/1212:01TYS - JNB
3 stops32h 54mMultiple Airlines
Wed 14/119:05JNB - TYS
2 stops29h 48mMultiple Airlines
Deal found 27/10R26 300
Wed 31/1211:00TYS - JNB
2 stops39h 30mLufthansa
Mon 12/119:45JNB - TYS
2 stops30h 42mLufthansa
Deal found 27/10R27 057
Wed 31/1216:29TYS - JNB
2 stops32h 06mAmerican Airlines
Mon 12/122:00JNB - TYS
2 stops29h 56mAmerican Airlines
Deal found 28/10R27 625
Fri 6/37:00TYS - CPT
2 stops45h 00mUnited Airlines
Fri 13/320:50CPT - TYS
1 stop24h 06mUnited Airlines
Deal found 26/10R29 121
Thu 1/111:11TYS - JNB
1 stop24h 49mDelta
Fri 16/123:59JNB - TYS
2 stops27h 48mDelta
Deal found 27/10R30 325
Thu 1/111:11TYS - JNB
1 stop24h 49mDelta
Thu 15/123:59JNB - TYS
2 stops41h 18mDelta
Deal found 27/10R30 411
Thu 11/1219:25TYS - CPT
2 stops29h 15mLufthansa
Thu 18/1218:45CPT - TYS
2 stops36h 14mLufthansa
Deal found 26/10R31 030

Find flights from Knoxville within your budget

 
Find flights departing from Knoxville that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 29 October 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Thu 12/3

19:00-10:25

2 stops33h 25m

Johannesburg OR Tambo

Mon 16/3

22:00-19:17

2 stops27h 17m

R21 260

KnoxvilleCape Town

TYS - CPT

TYSCPT

Knoxville McGhee Tyson

Sat 21/3

20:31-8:05

2 stops29h 34m

Cape Town Intl

Wed 25/3

20:35-19:17

2 stops28h 42m

R23 582

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Thu 1/1

16:12-7:35

2 stops32h 23m

Johannesburg OR Tambo

Thu 15/1

22:00-21:21

2 stops30h 21m

R24 701

KnoxvilleCape Town

TYS - CPT

TYSCPT

Knoxville McGhee Tyson

Fri 6/3

16:15-8:05

2 stops32h 50m

Cape Town Intl

Fri 13/3

20:50-21:29

2 stops30h 39m

R24 873

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Wed 31/12

12:01-3:55

3 stops32h 54m

Johannesburg OR Tambo

Wed 14/1

19:05-17:53

2 stops29h 48m

R26 300

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Wed 31/12

11:00-9:30

2 stops39h 30m

Johannesburg OR Tambo

Mon 12/1

19:45-19:27

2 stops30h 42m

R27 057

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Wed 31/12

16:29-7:35

2 stops32h 06m

Johannesburg OR Tambo

Mon 12/1

22:00-20:56

2 stops29h 56m

R27 625

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Thu 1/1

11:11-19:00

1 stop24h 49m

Johannesburg OR Tambo

Fri 16/1

23:59-20:47

2 stops27h 48m

R30 325

KnoxvilleJohannesburg

TYS - JNB

TYSJNB

Knoxville McGhee Tyson

Thu 1/1

11:11-19:00

1 stop24h 49m

Johannesburg OR Tambo

Thu 15/1

23:59-10:17

2 stops41h 18m

R30 411

KnoxvilleCape Town

TYS - CPT

TYSCPT

Knoxville McGhee Tyson

Thu 11/12

19:25-7:40

2 stops29h 15m

Cape Town Intl

Thu 18/12

18:45-23:59

2 stops36h 14m

R31 030

Flights are sorted by cheapest return flights first.

Deals found on 27/10

Showing 1-10 of 21 results
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Estimated return price
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Travel insights for flights from Knoxville

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Related info for your journey

Access useful and relevant information related to your journey from Knoxville. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 29 October 2025.

  • What are the most popular destinations to fly to from Knoxville?

    The most selected flight destinations from Knoxville for the current month are Boston, Fort Lauderdale, Denver. While Denver, Fort Lauderdale, Boston are the top choices made by travellers year-round.

  • How does Cheapflights help users find flights from Knoxville?

    Cheapflights makes it easy to find flights from Knoxville by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

  • Why should you use Cheapflights to find cheap flight tickets from Knoxville?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Knoxville.

  • Can Cheapflights find flights from Knoxville with no change fees?

    Yes, we can. To see specific flights from Knoxville with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Knoxville become cheaper?

    Of course! You can now track prices for flights from Knoxville and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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How does Cheapflights help users find flights from Knoxville?

Cheapflights makes it easy to find flights from Knoxville by helping our users search from 900+ travel sites for deals. We also provide you with filters for cabin, price, airline, airports, number of stops, and many more to narrow down that perfect flight.

Why should you use Cheapflights to find cheap flight tickets from Knoxville?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Knoxville.

Can Cheapflights find flights from Knoxville with no change fees?

Yes, we can. To see specific flights from Knoxville with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Knoxville become cheaper?

Of course! You can now track prices for flights from Knoxville and get an alert from Cheapflights when they change. Click the bell icon next to the flight deals above and provide your email address to set up price alerts.

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