R3 577+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
May 10 — May 171
1 adult
1 adult, Economy, 0 bags

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 10 April 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 10/8

7:55-18:30

2 stops27h 35m

Johannesburg OR Tambo

Sun 30/8

19:00-10:33

2 stops46h 33m

R20 823

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 10/8

7:55-18:30

2 stops27h 35m

Johannesburg OR Tambo

Mon 31/8

19:00-20:34

2 stops32h 34m

R20 823

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sat 20/6

22:29-8:35

2 stops51h 06m

Johannesburg OR Tambo

Sun 5/7

19:00-20:34

2 stops32h 34m

R22 612

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 28/8

22:29-8:35

2 stops51h 06m

Johannesburg OR Tambo

Mon 7/9

19:00-19:31

2 stops31h 31m

R23 908

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 4/5

18:50-21:20

1 stop43h 30m

Johannesburg OR Tambo

Thu 14/5

23:15-19:45

2 stops51h 30m

R27 617

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 28/4

9:13-18:30

2 stops26h 17m

Johannesburg OR Tambo

Wed 13/5

19:00-14:14

2 stops50h 14m

R27 896

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 6/5

9:39-18:30

2 stops25h 51m

Johannesburg OR Tambo

Wed 13/5

19:00-20:34

2 stops32h 34m

R28 257

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 29/4

9:39-18:30

2 stops25h 51m

Johannesburg OR Tambo

Mon 11/5

19:00-20:41

2 stops32h 41m

R28 257

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 3/5

9:39-18:30

2 stops25h 51m

Johannesburg OR Tambo

Mon 11/5

19:00-6:13

2 stops42h 13m

R28 257

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 22/5

22:29-8:35

2 stops51h 06m

Johannesburg OR Tambo

Sat 6/6

22:00-18:37

2 stops27h 37m

R28 290

Flights are sorted by cheapest return flights first.

Deals found on 6/4

Showing 1-10 of 34 resultsSorted by cheapest first
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama?

Currently, September is the cheapest month in which you can book a flight from Panama (average of R13 144). Flying from Panama in December will prove the most costly (average of R37 741). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 264. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 264
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 803
San José Juan Santamaria Intl
San José Juan Santamaria Intl
From R2 252
Madrid Barajas
Madrid Barajas
From R16 624

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Direct flights from Central America

Book a direct flight from one of these other cities located in Central America.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 10 April 2026.

  • What is the cheapest month to fly from Panama?

    September is currently the cheapest month to fly from Panama. At this moment in time December is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

See more FAQs

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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