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R4 840+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 18/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Nov 22 — Nov 291
1 adult
1 adult, Economy

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 23 October 2025.

Good round-trip deal

R17 639 or less

Good one-way deal

R1 341 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

Enter your travel dates to find the best prices.

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 23 October 2025.

Wed 11/37:55PTY - CPT
2 stops26h 05mUnited Airlines
Tue 24/320:50CPT - PTY
2 stops26h 17mUnited Airlines
Deal found 22/10R17 289
Mon 9/29:11PTY - CPT
1 stop23h 59mUnited Airlines
Mon 23/220:50CPT - PTY
2 stops30h 45mUnited Airlines
Deal found 21/10R17 324
Mon 13/47:55PTY - JNB
2 stops26h 50mUnited Airlines
Mon 20/421:20JNB - PTY
2 stops26h 48mUnited Airlines
Deal found 21/10R17 324
Sat 14/312:04PTY - CPT
2 stops45h 56mUnited Airlines
Sun 22/320:50CPT - PTY
2 stops54h 45mUnited Airlines
Deal found 22/10R17 341
Thu 20/1112:04PTY - CPT
2 stops36h 36mUnited Airlines
Tue 25/1120:50CPT - PTY
2 stops48h 55mUnited Airlines
Deal found 22/10R17 933
Thu 12/318:41PTY - CPT
2 stops53h 59mUnited Airlines
Tue 24/320:50CPT - PTY
2 stops26h 17mUnited Airlines
Deal found 22/10R17 951
Sun 23/1117:51PTY - CPT
2 stops39h 19mUnited Airlines
Mon 1/1220:50CPT - PTY
2 stops27h 17mUnited Airlines
Deal found 22/10R18 264
Thu 20/119:30PTY - CPT
2 stops39h 10mUnited Airlines
Mon 1/1220:50CPT - PTY
2 stops27h 17mUnited Airlines
Deal found 22/10R18 856
Thu 12/318:41PTY - CPT
2 stops53h 59mUnited Airlines
Thu 19/318:45CPT - PTY
2 stops42h 28mUnited Airlines
Deal found 22/10R18 926
Wed 11/37:55PTY - CPT
2 stops26h 05mUnited Airlines
Mon 23/318:45CPT - PTY
2 stops40h 25mUnited Airlines
Deal found 22/10R19 187
Sun 23/1119:10PTY - CPT
2 stops38h 00mUnited Airlines
Sun 30/1118:45CPT - PTY
2 stops46h 48mUnited Airlines
Deal found 22/10R19 239
Fri 21/1118:41PTY - JNB
2 stops64h 54mMultiple Airlines
Sun 7/1215:05JNB - PTY
2 stops29h 26mMultiple Airlines
Deal found 21/10R19 274

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 23 October 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 15/3

18:41-16:10

1 stop38h 29m

Cape Town Intl

Tue 24/3

20:50-13:31

1 stop23h 41m

R17 289

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 19/11

9:30-18:00

2 stops25h 30m

Cape Town Intl

Tue 25/11

20:50-13:22

2 stops47h 32m

R17 289

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 11/3

7:55-17:00

2 stops26h 05m

Cape Town Intl

Tue 24/3

20:50-6:13

1 stop40h 23m

R17 289

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 17/3

8:16-17:00

2 stops25h 44m

Cape Town Intl

Tue 24/3

20:50-6:13

1 stop40h 23m

R17 289

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

9:11-16:10

1 stop23h 59m

Cape Town Intl

Mon 23/2

20:50-20:35

2 stops30h 45m

R17 324

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

7:55-17:45

2 stops26h 50m

Johannesburg OR Tambo

Mon 20/4

21:20-17:08

2 stops26h 48m

R17 324

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 13/3

22:29-16:10

1 stop34h 41m

Cape Town Intl

Wed 25/3

19:50-6:37

2 stops41h 47m

R17 341

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Thu 20/11

12:04-7:40

2 stops36h 36m

Cape Town Intl

Tue 25/11

20:50-14:45

2 stops48h 55m

R17 933

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Thu 12/3

22:29-7:40

2 stops50h 11m

Cape Town Intl

Tue 24/3

20:50-20:35

1 stop30h 45m

R17 951

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 23/11

17:51-16:10

2 stops39h 19m

Cape Town Intl

Mon 1/12

20:50-17:07

2 stops27h 17m

R18 264

Flights are sorted by cheapest return flights first.

Deals found on 21/10

Showing 1-10 of 25 results
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama?

Currently, September is the cheapest month in which you can book a flight from Panama (average of R14 190). Flying from Panama in August will prove the most costly (average of R40 794). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Panama?

When flying from Panama check dates and pricing for the following: United Airlines. As it departs for the following popular destinations: Johannesburg.

United Airlines
United Airlines
From R17 659

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 341. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 341
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 913
Madrid Barajas
Madrid Barajas
From R17 639

Airline reviews for flights from Panama

Get insights into the airlines that provide service from Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama. In the last 7 days, Cheapflights users made a total of 594 507 searches.
Get a feel of what it's like to fly with United Airlines from Panama by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7,4
Good
8 990 reviews
Check prices

Boarding

7,7

Comfort

7,3

Overall

7,4

Food

6,6

Crew

8,1

Entertainment

7,1

Reviews

1 / 20
10,0
Excellent

Anonymous,Sept 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.
United Airlines
7,4
Good
8 990 reviews
United Airlines
7,4
Good
8 990 reviews
Check prices

Boarding

7,7

Comfort

7,3

Overall

7,4

Food

6,6

Crew

8,1

Entertainment

7,1

Reviews

1 / 20
10,0
Excellent

Anonymous,Sept 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.

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Direct flights from Central America

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 23 October 2025.

  • What is the cheapest month to fly from Panama?

    September is currently the cheapest month to fly from Panama. At this moment in time August is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

See more FAQs

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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