R5 406+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — CPT
Jan 5 — Jan 121
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 6 December 2025.

Good round-trip deal

R17 167 or less

Good one-way deal

R1 305 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

Enter your travel dates to find the best prices.

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 6 December 2025.

Fri 15/518:28PTY - CPT
2 stops32h 02mLufthansa
Tue 26/518:05CPT - PTY
2 stops45h 44mLufthansa
Deal found 5/12R15 539
Thu 12/218:31PTY - JNB
2 stops31h 59mLufthansa
Wed 11/319:45JNB - PTY
2 stops44h 06mLufthansa
Deal found 5/12R15 674
Mon 9/222:29PTY - CPT
2 stops36h 31mUnited Airlines
Tue 17/220:50CPT - PTY
2 stops30h 45mUnited Airlines
Deal found 5/12R16 877
Mon 9/222:29PTY - CPT
2 stops36h 31mUnited Airlines
Thu 12/319:50CPT - PTY
2 stops31h 45mUnited Airlines
Deal found 5/12R17 098
Tue 14/48:11PTY - JNB
2 stops27h 19mUnited Airlines
Sun 3/515:05JNB - PTY
2 stops29h 26mUnited Airlines
Deal found 4/12R17 132
Mon 9/29:11PTY - JNB
2 stops26h 24mUnited Airlines
Fri 13/310:25JNB - PTY
2 stops41h 10mUnited Airlines
Deal found 5/12R17 199
Fri 17/418:41PTY - JNB
2 stops42h 49mUnited Airlines
Sun 3/515:05JNB - PTY
2 stops29h 26mUnited Airlines
Deal found 4/12R17 301
Tue 20/112:04PTY - CPT
2 stops36h 36mUnited Airlines
Tue 10/220:50CPT - PTY
1 stop23h 41mUnited Airlines
Deal found 5/12R17 471
Fri 17/49:12PTY - JNB
2 stops40h 23mMultiple Airlines
Sat 2/519:00JNB - PTY
2 stops44h 49mMultiple Airlines
Deal found 4/12R17 521
Thu 12/217:51PTY - CPT
2 stops63h 19mUnited Airlines
Thu 12/319:50CPT - PTY
2 stops41h 23mUnited Airlines
Deal found 5/12R17 776
Tue 14/47:55PTY - JNB
2 stops27h 35mUnited Airlines
Wed 29/419:00JNB - PTY
2 stops42h 13mUnited Airlines
Deal found 4/12R17 809
Fri 15/59:45PTY - CPT
2 stops40h 45mUnited Airlines
Tue 26/520:00CPT - PTY
1 stop24h 31mUnited Airlines
Deal found 5/12R17 826

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 6 December 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Cape Town

Route

Depart

Return

Price

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 10/2

7:55-18:00

2 stops27h 05m

Cape Town Intl

Tue 17/2

20:50-20:35

2 stops30h 45m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 15/2

22:29-16:10

1 stop34h 41m

Cape Town Intl

Mon 9/3

19:50-20:27

2 stops31h 37m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 10/2

9:11-18:00

2 stops25h 49m

Cape Town Intl

Thu 19/2

20:50-20:35

2 stops30h 45m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 18/1

18:41-16:10

1 stop38h 29m

Cape Town Intl

Sun 25/1

20:50-20:35

1 stop30h 45m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

9:11-16:10

1 stop23h 59m

Cape Town Intl

Tue 17/2

20:50-13:31

1 stop23h 41m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

22:29-18:00

2 stops36h 31m

Cape Town Intl

Thu 19/2

20:50-17:08

2 stops27h 18m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

9:11-16:10

1 stop23h 59m

Cape Town Intl

Fri 20/2

20:50-20:35

1 stop30h 45m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 15/2

16:41-16:10

2 stops40h 29m

Cape Town Intl

Tue 10/3

20:50-13:31

1 stop23h 41m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 10/2

7:55-18:00

2 stops27h 05m

Cape Town Intl

Wed 18/2

20:50-20:35

2 stops30h 45m

R16 877

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 15/2

16:41-16:10

2 stops40h 29m

Cape Town Intl

Thu 12/3

19:50-20:35

2 stops31h 45m

R17 098

Flights are sorted by cheapest return flights first.

Deals found on 4/12

Showing 1-10 of 31 results
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 305. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 305
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 862
Madrid Barajas
Madrid Barajas
From R17 167

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Direct flights from Central America

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 6 December 2025.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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