R5 290+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 29/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — CPT
feb. 26 — mar. 51
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 27 enero 2026.

Good round-trip deal

R16 240 or less

Good one-way deal

R1 234 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

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Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 27 enero 2026.

lun. 2/318:31
PTY
-
JNB
2 stops31h 59m
Lufthansa
mar. 31/319:00
JNB
-
PTY
2 stops42h 48m
Lufthansa
Deal found 25/1R14 972
mié. 4/37:55
PTY
-
JNB
2 stops27h 40m
United Airlines
mar. 10/319:45
JNB
-
PTY
2 stops31h 50m
United Airlines
Deal found 26/1R16 896
sáb. 25/49:13
PTY
-
CPT
1 stop23h 07m
United Airlines
vie. 1/517:55
CPT
-
PTY
2 stops50h 27m
United Airlines
Deal found 26/1R16 928
mié. 18/27:55
PTY
-
JNB
2 stops27h 40m
United Airlines
dom. 22/219:45
JNB
-
PTY
2 stops41h 28m
United Airlines
Deal found 25/1R17 040
mié. 10/68:10
PTY
-
JNB
2 stops41h 25m
United Airlines
mié. 24/619:00
JNB
-
PTY
2 stops50h 22m
United Airlines
Deal found 25/1R17 825
lun. 2/321:45
PTY
-
JNB
1 stop30h 05m
Turkish Airlines
mar. 31/317:50
JNB
-
PTY
2 stops31h 35m
Turkish Airlines
Deal found 25/1R18 066
mié. 4/321:45
PTY
-
JNB
1 stop30h 05m
Turkish Airlines
mar. 10/319:10
JNB
-
PTY
2 stops28h 55m
Turkish Airlines
Deal found 26/1R18 082
lun. 13/418:50
PTY
-
JNB
1 stop43h 30m
Multiple Airlines
lun. 20/418:00
JNB
-
PTY
1 stop32h 45m
Multiple Airlines
Deal found 25/1R18 210
lun. 13/421:55
PTY
-
JNB
2 stops40h 25m
KLM
lun. 20/418:00
JNB
-
PTY
2 stops29h 50m
KLM
Deal found 26/1R18 643
sáb. 25/418:50
PTY
-
CPT
1 stop43h 35m
KLM
vie. 1/57:40
CPT
-
PTY
1 stop40h 10m
KLM
Deal found 26/1R18 707
lun. 9/29:11
PTY
-
CPT
1 stop23h 59m
United Airlines
lun. 23/218:45
CPT
-
PTY
2 stops56h 50m
United Airlines
Deal found 25/1R20 326
lun. 9/318:41
PTY
-
CPT
2 stops39h 14m
United Airlines
vie. 27/39:30
CPT
-
PTY
2 stops51h 43m
United Airlines
Deal found 26/1R20 342

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 27 enero 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Cape Town

Route

Depart

Return

Price

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

mié. 4/3

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

mar. 10/3

19:45-6:13

2 stops41h 28m

R16 896

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

sáb. 25/4

19:25-15:20

2 stops60h 55m

Cape Town Intl

sáb. 9/5

17:55-20:41

2 stops33h 46m

R16 928

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

sáb. 25/4

9:13-15:20

1 stop23h 07m

Cape Town Intl

vie. 1/5

17:55-13:22

2 stops50h 27m

R16 928

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

mié. 18/2

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

dom. 22/2

19:45-6:13

2 stops41h 28m

R17 040

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

mié. 4/3

21:45-10:50

1 stop30h 05m

Johannesburg OR Tambo

mar. 10/3

19:10-17:05

2 stops28h 55m

R18 066

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

lun. 2/3

21:45-10:50

1 stop30h 05m

Johannesburg OR Tambo

mar. 31/3

17:50-20:25

1 stop33h 35m

R18 066

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

lun. 13/4

18:50-21:20

1 stop43h 30m

Johannesburg OR Tambo

lun. 20/4

18:00-19:45

1 stop32h 45m

R18 082

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

sáb. 25/4

18:50-21:25

1 stop43h 35m

Cape Town Intl

vie. 1/5

7:40-16:50

1 stop40h 10m

R18 707

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

lun. 9/2

9:11-16:10

1 stop23h 59m

Cape Town Intl

lun. 23/2

18:45-13:31

2 stops49h 46m

R20 326

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

mié. 18/3

18:09-15:05

2 stops37h 56m

Cape Town Intl

dom. 22/3

18:45-6:13

2 stops42h 28m

R20 470

Flights are sorted by cheapest return flights first.

Deals found on 25/1

Showing 1-10 of 19 results
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 234. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 234
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 762
Istanbul
Istanbul
From R15 772
Madrid Barajas
Madrid Barajas
From R16 240

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Direct flights from Central America

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 27 enero 2026.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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