R4 699+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 18/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — CPT
Dec 12 — Dec 191
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 12 November 2025.

Good round-trip deal

R17 372 or less

Good one-way deal

R1 320 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

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Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 12 November 2025.

Thu 5/29:11PTY - CPT
1 stop23h 59mUnited Airlines
Wed 11/319:50CPT - PTY
2 stops31h 45mUnited Airlines
Deal found 12/11R17 079
Wed 15/47:55PTY - JNB
2 stops26h 50mUnited Airlines
Sun 3/515:05JNB - PTY
2 stops29h 26mUnited Airlines
Deal found 9/11R17 234
Sun 1/218:27PTY - CPT
2 stops38h 43mAir Canada
Sun 8/220:50CPT - PTY
1 stop23h 41mAir Canada
Deal found 11/11R17 474
Thu 16/49:11PTY - JNB
2 stops28h 19mUnited Airlines
Sun 3/515:05JNB - PTY
2 stops46h 08mUnited Airlines
Deal found 9/11R17 491
Sun 1/222:29PTY - CPT
1 stop34h 41mUnited Airlines
Mon 9/220:50CPT - PTY
2 stops27h 18mUnited Airlines
Deal found 11/11R17 988
Mon 9/29:11PTY - CPT
1 stop23h 59mUnited Airlines
Mon 23/218:45CPT - PTY
2 stops42h 28mUnited Airlines
Deal found 12/11R18 023
Wed 15/47:55PTY - JNB
2 stops26h 50mUnited Airlines
Wed 29/419:00JNB - PTY
2 stops42h 13mUnited Airlines
Deal found 9/11R18 023
Thu 19/29:11PTY - CPT
1 stop23h 59mUnited Airlines
Sat 14/318:45CPT - PTY
2 stops42h 28mUnited Airlines
Deal found 12/11R18 040
Mon 13/49:11PTY - JNB
2 stops25h 34mUnited Airlines
Mon 20/419:00JNB - PTY
2 stops42h 13mUnited Airlines
Deal found 12/11R18 040
Thu 16/49:11PTY - JNB
2 stops28h 19mUnited Airlines
Fri 1/519:00JNB - PTY
2 stops42h 13mUnited Airlines
Deal found 9/11R18 211
Thu 16/49:11PTY - JNB
2 stops28h 19mUnited Airlines
Wed 29/419:00JNB - PTY
2 stops32h 35mUnited Airlines
Deal found 9/11R18 280
Sun 1/218:27PTY - CPT
2 stops38h 43mAir Canada
Mon 9/218:45CPT - PTY
2 stops32h 50mAir Canada
Deal found 11/11R18 434

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 12 November 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Cape Town

Route

Depart

Return

Price

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 1/2

7:55-18:00

2 stops27h 05m

Cape Town Intl

Sun 8/2

20:50-6:13

1 stop40h 23m

R17 079

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 31/1

8:16-16:10

2 stops24h 54m

Cape Town Intl

Sun 8/2

20:50-17:08

2 stops27h 18m

R17 079

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 31/1

8:16-16:10

2 stops24h 54m

Cape Town Intl

Sat 7/2

20:50-19:38

2 stops29h 48m

R17 079

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 28/1

8:16-18:00

2 stops26h 44m

Cape Town Intl

Wed 4/2

20:50-20:35

2 stops30h 45m

R17 079

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sat 18/4

8:10-17:45

2 stops26h 35m

Johannesburg OR Tambo

Tue 5/5

15:05-13:31

2 stops29h 26m

R17 234

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 15/4

7:55-17:45

2 stops26h 50m

Johannesburg OR Tambo

Tue 5/5

15:05-13:31

2 stops29h 26m

R17 234

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 20/4

7:55-17:45

2 stops26h 50m

Johannesburg OR Tambo

Tue 5/5

15:05-20:35

2 stops36h 30m

R17 234

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 19/4

22:29-17:45

2 stops36h 16m

Johannesburg OR Tambo

Sun 3/5

15:05-20:35

2 stops36h 30m

R17 234

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Thu 16/4

9:11-20:30

2 stops28h 19m

Johannesburg OR Tambo

Sun 3/5

15:05-6:13

2 stops46h 08m

R17 491

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 1/2

22:29-16:10

1 stop34h 41m

Cape Town Intl

Mon 9/2

20:50-17:08

2 stops27h 18m

R17 988

Flights are sorted by cheapest return flights first.

Deals found on 10/11

Showing 1-10 of 31 results
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 320. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 320
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 885
Madrid Barajas
Madrid Barajas
From R17 372

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Direct flights from Central America

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 12 November 2025.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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