R4 246+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 29/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — CPT
feb. 17 — feb. 241
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 18 enero 2026.

Good round-trip deal

R16 608 or less

Good one-way deal

R1 262 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

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Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 18 enero 2026.

vie. 24/418:28
PTY
-
CPT
2 stops32h 02m
Lufthansa
sáb. 9/517:55
CPT
-
PTY
2 stops43h 53m
Lufthansa
Deal found 16/1R15 410
lun. 16/218:31
PTY
-
JNB
2 stops31h 59m
Lufthansa
lun. 23/219:45
JNB
-
PTY
2 stops41h 53m
Lufthansa
Deal found 17/1R15 410
vie. 30/18:16
PTY
-
CPT
2 stops26h 44m
United Airlines
mié. 4/220:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 16/1R16 328
mar. 3/316:41
PTY
-
CPT
2 stops42h 19m
United Airlines
mar. 10/320:50
CPT
-
PTY
1 stop30h 45m
United Airlines
Deal found 17/1R16 344
mié. 11/29:30
PTY
-
CPT
2 stops25h 30m
United Airlines
jue. 19/320:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 17/1R16 574
lun. 2/39:11
PTY
-
CPT
1 stop23h 59m
United Airlines
lun. 9/318:45
CPT
-
PTY
2 stops56h 50m
United Airlines
Deal found 16/1R17 279
dom. 15/27:55
PTY
-
JNB
2 stops27h 40m
United Airlines
mié. 4/319:45
JNB
-
PTY
2 stops41h 52m
United Airlines
Deal found 16/1R17 279
mié. 1/422:20
PTY
-
JNB
1 stop29h 10m
Turkish Airlines
vie. 3/418:00
JNB
-
PTY
1 stop33h 25m
Turkish Airlines
Deal found 16/1R17 361
mié. 29/418:50
PTY
-
CPT
1 stop43h 35m
KLM
mié. 13/523:15
CPT
-
PTY
1 stop24h 35m
KLM
Deal found 15/1R17 541
lun. 13/418:50
PTY
-
JNB
1 stop43h 30m
KLM
lun. 20/423:15
JNB
-
PTY
2 stops27h 30m
KLM
Deal found 16/1R18 115
vie. 6/222:29
PTY
-
CPT
1 stop34h 41m
United Airlines
dom. 22/318:45
CPT
-
PTY
2 stops46h 48m
United Airlines
Deal found 15/1R18 148
mié. 18/27:55
PTY
-
JNB
2 stops27h 40m
United Airlines
dom. 22/219:45
JNB
-
PTY
2 stops48h 46m
United Airlines
Deal found 17/1R18 180

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 18 enero 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Cape Town

Route

Depart

Return

Price

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

lun. 16/2

18:31-9:30

2 stops31h 59m

Johannesburg OR Tambo

lun. 23/2

19:45-6:38

2 stops41h 53m

R15 410

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

vie. 30/1

8:16-18:00

2 stops26h 44m

Cape Town Intl

mié. 4/2

20:50-20:35

2 stops30h 45m

R16 328

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

mar. 3/3

16:41-18:00

2 stops42h 19m

Cape Town Intl

mar. 10/3

20:50-20:35

1 stop30h 45m

R16 344

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

sáb. 25/4

9:13-15:20

1 stop23h 07m

Cape Town Intl

sáb. 9/5

17:55-14:22

2 stops51h 27m

R17 279

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

dom. 15/2

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

mié. 4/3

19:45-6:37

2 stops41h 52m

R17 279

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

lun. 13/4

22:20-10:30

1 stop29h 10m

Johannesburg OR Tambo

lun. 20/4

18:00-18:25

1 stop31h 25m

R17 361

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

mié. 1/4

22:20-10:30

1 stop29h 10m

Johannesburg OR Tambo

vie. 3/4

18:00-20:25

1 stop33h 25m

R17 361

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

mié. 18/2

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

dom. 22/2

19:45-6:13

2 stops41h 28m

R17 426

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

mié. 29/4

18:50-21:25

1 stop43h 35m

Cape Town Intl

mié. 13/5

23:15-16:50

1 stop24h 35m

R17 541

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

lun. 13/4

18:50-21:20

1 stop43h 30m

Johannesburg OR Tambo

lun. 20/4

23:15-19:45

2 stops27h 30m

R18 115

Flights are sorted by cheapest return flights first.

Deals found on 16/1

Showing 1-10 of 20 results
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 262. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 262
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 802
Istanbul
Istanbul
From R16 130
Madrid Barajas
Madrid Barajas
From R16 608

Browse thousands of different options on Cheapflights for your next trip

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Direct flights from Central America

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 18 enero 2026.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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