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R4 743+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 18/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Dec 5 — Dec 121
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 5 November 2025.

Good round-trip deal

R17 667 or less

Good one-way deal

R1 343 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

Enter your travel dates to find the best prices.

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 5 November 2025.

Mon 9/29:11PTY - CPT
1 stop23h 59mUnited Airlines
Sun 22/220:50CPT - PTY
2 stops44h 43mUnited Airlines
Deal found 3/11R17 369
Wed 3/128:16PTY - CPT
2 stops26h 44mUnited Airlines
Wed 10/129:30CPT - PTY
2 stops56h 03mUnited Airlines
Deal found 5/11R18 293
Mon 9/29:11PTY - CPT
1 stop23h 59mUnited Airlines
Mon 23/218:45CPT - PTY
2 stops49h 46mUnited Airlines
Deal found 4/11R18 328
Wed 28/18:16PTY - JNB
2 stops27h 19mUnited Airlines
Wed 25/319:45JNB - PTY
2 stops41h 28mUnited Airlines
Deal found 4/11R18 328
Tue 2/1219:20PTY - JNB
2 stops55h 10mUnited Airlines
Tue 9/1219:45JNB - PTY
2 stops31h 50mUnited Airlines
Deal found 2/11R19 305
Sun 8/218:45PTY - CPT
2 stops52h 05mKLM
Thu 12/218:25CPT - PTY
2 stops29h 05mKLM
Deal found 4/11R19 392
Mon 9/218:45PTY - CPT
1 stop34h 05mTurkish Airlines
Mon 23/217:15CPT - PTY
1 stop30h 50mTurkish Airlines
Deal found 3/11R20 578
Wed 3/1218:45PTY - CPT
1 stop44h 10mMultiple Airlines
Wed 10/127:55CPT - PTY
1 stop43h 15mMultiple Airlines
Deal found 5/11R20 962
Tue 17/32:55PTY - CPT
3 stops45h 35mMultiple Airlines
Tue 24/30:30CPT - PTY
3 stops31h 10mMultiple Airlines
Deal found 4/11R21 432
Wed 28/122:05PTY - JNB
1 stop41h 00mKLM
Wed 25/323:59JNB - PTY
1 stop23h 31mKLM
Deal found 4/11R22 671
Tue 2/1222:20PTY - JNB
1 stop30h 50mAir France
Tue 9/1219:20JNB - PTY
1 stop31h 50mAir France
Deal found 2/11R22 688
Sun 8/218:45PTY - CPT
1 stop34h 05mTurkish Airlines
Thu 12/217:15CPT - PTY
2 stops30h 50mTurkish Airlines
Deal found 2/11R23 595

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 5 November 2025. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

9:11-16:10

1 stop23h 59m

Cape Town Intl

Sun 22/2

20:50-10:33

2 stops44h 43m

R17 369

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 18/3

8:16-17:00

2 stops25h 44m

Cape Town Intl

Wed 25/3

19:50-20:35

2 stops31h 45m

R18 293

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 3/12

8:16-18:00

2 stops26h 44m

Cape Town Intl

Wed 10/12

9:30-10:33

2 stops56h 03m

R18 293

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

9:11-16:10

1 stop23h 59m

Cape Town Intl

Mon 23/2

18:45-6:13

2 stops42h 28m

R18 328

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 17/2

12:56-18:35

2 stops46h 39m

Johannesburg OR Tambo

Tue 19/5

19:00-20:35

2 stops32h 35m

R18 328

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 28/1

8:16-18:35

2 stops27h 19m

Johannesburg OR Tambo

Wed 25/3

19:45-6:13

2 stops41h 28m

R18 328

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 2/12

19:20-9:30

2 stops55h 10m

Johannesburg OR Tambo

Tue 9/12

19:45-20:35

2 stops31h 50m

R19 305

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 8/2

18:45-5:50

2 stops52h 05m

Cape Town Intl

Thu 12/2

18:25-16:30

2 stops29h 05m

R19 392

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 9/2

18:45-11:50

1 stop34h 05m

Cape Town Intl

Mon 23/2

17:15-17:05

1 stop30h 50m

R20 578

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 3/12

18:45-21:55

1 stop44h 10m

Cape Town Intl

Wed 10/12

7:55-20:10

1 stop43h 15m

R20 962

Flights are sorted by cheapest return flights first.

Deals found on 3/11

Showing 1-10 of 27 results
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama?

Currently, September is the cheapest month in which you can book a flight from Panama (average of R14 213). Flying from Panama in August will prove the most costly (average of R40 859). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

Which airlines fly from Panama?

When flying from Panama check dates and pricing for the following: United Airlines. As it departs for the following popular destinations: Johannesburg.

United Airlines
United Airlines
From R17 687

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 343. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 343
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 917
Madrid Barajas
Madrid Barajas
From R17 667

Airline reviews for flights from Panama

Get insights into the airlines that provide service from Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama. In the last 7 days, Cheapflights users made a total of 594 507 searches.
Get a feel of what it's like to fly with United Airlines from Panama by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7,4
Good
9 002 reviews
Check prices

Food

6,6

Comfort

7,3

Crew

8,1

Entertainment

7,1

Boarding

7,7

Overall

7,4

Reviews

1 / 20
10,0
Excellent

Anonymous,Sept 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.
United Airlines
7,4
Good
9 002 reviews
United Airlines
7,4
Good
9 002 reviews
Check prices

Food

6,6

Comfort

7,3

Crew

8,1

Entertainment

7,1

Boarding

7,7

Overall

7,4

Reviews

1 / 20
10,0
Excellent

Anonymous,Sept 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.

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Direct flights from Central America

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 5 November 2025.

  • What is the cheapest month to fly from Panama?

    September is currently the cheapest month to fly from Panama. At this moment in time August is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

See more FAQs

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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