R3 452+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 18/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Apr 9 — Apr 161
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 10 March 2026.

Good round-trip deal

R16 495 or less

Good one-way deal

R1 254 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

Enter your travel dates to find the best prices.

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 10 March 2026.

Sun 3/518:31
PTY
-
JNB
2 stops31h 04m
Lufthansa
Sun 17/519:00
JNB
-
PTY
2 stops42h 48m
Lufthansa
Deal found 9/3R15 175
Wed 8/418:31
PTY
-
JNB
2 stops31h 04m
Lufthansa
Thu 23/419:00
JNB
-
PTY
2 stops42h 48m
Lufthansa
Deal found 9/3R16 006
Mon 13/49:13
PTY
-
JNB
2 stops26h 17m
United Airlines
Mon 20/419:00
JNB
-
PTY
2 stops49h 31m
United Airlines
Deal found 10/3R17 162
Tue 1/98:11
PTY
-
JNB
2 stops27h 19m
United Airlines
Tue 22/919:00
JNB
-
PTY
2 stops42h 37m
United Airlines
Deal found 9/3R17 178
Fri 8/57:55
PTY
-
JNB
2 stops27h 35m
United Airlines
Mon 11/519:00
JNB
-
PTY
2 stops42h 13m
United Airlines
Deal found 6/3R17 324
Sun 3/520:05
PTY
-
JNB
1 stop31h 25m
Turkish Airlines
Sun 17/518:00
JNB
-
PTY
1 stop33h 25m
Turkish Airlines
Deal found 9/3R18 204
Thu 18/64:25
PTY
-
JNB
2 stops24h 35m
Multiple Airlines
Thu 2/77:30
JNB
-
PTY
3 stops37h 45m
Multiple Airlines
Deal found 9/3R20 402
Wed 8/422:29
PTY
-
JNB
2 stops37h 01m
United Airlines
Wed 15/419:00
JNB
-
PTY
2 stops32h 34m
United Airlines
Deal found 10/3R20 662
Fri 12/618:31
PTY
-
JNB
2 stops31h 04m
Lufthansa
Sun 28/619:00
JNB
-
PTY
2 stops42h 48m
Lufthansa
Deal found 9/3R20 793
Wed 22/418:50
PTY
-
CPT
1 stop43h 35m
KLM
Wed 29/47:40
CPT
-
PTY
1 stop40h 10m
KLM
Deal found 8/3R21 411
Wed 8/418:31
PTY
-
CPT
2 stops31h 59m
Multiple Airlines
Wed 15/418:25
CPT
-
PTY
2 stops44h 36m
Multiple Airlines
Deal found 9/3R28 901
Fri 8/59:45
PTY
-
CPT
2 stops40h 45m
United Airlines
Mon 11/519:50
CPT
-
PTY
2 stops27h 22m
United Airlines
Deal found 7/3R29 080

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 10 March 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 1/9

9:39-18:30

2 stops25h 51m

Johannesburg OR Tambo

Tue 22/9

19:00-6:13

2 stops42h 13m

R17 178

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 8/5

7:55-18:30

2 stops27h 35m

Johannesburg OR Tambo

Mon 11/5

19:00-6:13

2 stops42h 13m

R17 324

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 17/6

7:55-8:35

2 stops41h 40m

Johannesburg OR Tambo

Sat 4/7

19:00-13:22

2 stops49h 22m

R21 574

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 16/6

18:27-8:35

2 stops55h 08m

Johannesburg OR Tambo

Sat 4/7

19:00-20:41

2 stops32h 41m

R21 574

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 22/4

18:50-21:45

2 stops43h 55m

Cape Town Intl

Wed 29/4

7:40-16:50

1 stop40h 10m

R21 835

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 17/6

18:50-21:20

1 stop43h 30m

Johannesburg OR Tambo

Wed 1/7

23:15-19:45

2 stops27h 30m

R25 042

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 26/7

20:25-9:50

1 stop30h 25m

Johannesburg OR Tambo

Tue 11/8

18:55-18:40

1 stop30h 45m

R25 596
Fastest return journey

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

22:20-10:30

1 stop29h 10m

Johannesburg OR Tambo

Mon 20/4

18:00-18:25

2 stops31h 25m

R28 348

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 8/5

9:13-9:30

2 stops41h 17m

Cape Town Intl

Mon 11/5

19:50-16:12

2 stops27h 22m

R29 080

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 7/4

20:05-11:50

1 stop32h 45m

Cape Town Intl

Tue 14/4

16:35-20:25

1 stop34h 50m

R35 463

Flights are sorted by cheapest return flights first.

Deals found on 8/3

Showing 1-10 of 21 resultsSorted by cheapest first
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Panama?

Currently, September is the cheapest month in which you can book a flight from Panama (average of R13 042). Flying from Panama in December will prove the most costly (average of R37 449). There are multiple factors that influence the price of a flight so comparing airlines, departure airports and times can help keep costs down.

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 254. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 254
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 789
Madrid Barajas
Madrid Barajas
From R16 495

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Direct flights from Central America

Book a direct flight from one of these other cities located in Central America.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 10 March 2026.

  • What is the cheapest month to fly from Panama?

    September is currently the cheapest month to fly from Panama. At this moment in time December is the most expensive month. These prices are determined by multiple factors and booking in advance can help keep costs down if your schedule is not as flexible.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

See more FAQs

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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