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R4 120+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 29/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — JNB
Feb 3 — Feb 101
1 adult
1 adult, Economy, 0 bags

What to know about flights from Panama

Discover essential information about flights departing from Panama, including flight schedules, destinations, airlines operating at the Panama airport, and any specific guidelines or requirements for travellers. Please note that the information is based on the most recent updates available. Data last updated 4 January 2026.

Good round-trip deal

R16 698 or less

Good one-way deal

R1 269 or less
Price to beat on a round-trip flight from Panama.
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Price to beat on a one-way flight from Panama.
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Find flights from Panama

Enter your travel dates to find the best prices.

Cheapest flights from Panama
Explore the most affordable flight options available from Panama. Find the lowest fares based on data from user searches, with prices last updated on 4 January 2026.

Wed 8/418:28PTY - JNB
2 stops31h 07mLufthansa
Tue 16/619:00JNB - PTY
2 stops44h 49mLufthansa
Deal found 1/1R15 312
Fri 30/18:10PTY - CPT
2 stops26h 50mUnited Airlines
Wed 4/220:50CPT - PTY
2 stops27h 17mUnited Airlines
Deal found 4/1R16 433
Tue 7/49:13PTY - JNB
2 stops26h 17mUnited Airlines
Tue 9/622:00JNB - PTY
2 stops47h 22mUnited Airlines
Deal found 4/1R16 433
Fri 30/19:30PTY - JNB
2 stops26h 05mUnited Airlines
Sat 7/222:00JNB - PTY
2 stops29h 27mUnited Airlines
Deal found 3/1R16 647
Mon 2/222:05PTY - JNB
1 stop41h 00mMultiple Airlines
Mon 9/219:20JNB - PTY
1 stop31h 50mMultiple Airlines
Deal found 2/1R16 762
Fri 23/18:55PTY - JNB
2 stops26h 40mUnited Airlines
Mon 26/119:45JNB - PTY
2 stops41h 52mUnited Airlines
Deal found 3/1R17 372
Mon 9/218:45PTY - CPT
2 stops28h 05mMultiple Airlines
Mon 23/214:00CPT - PTY
2 stops33h 30mMultiple Airlines
Deal found 4/1R17 487
Wed 18/315:41PTY - CPT
2 stops40h 24mUnited Airlines
Sun 22/318:45CPT - PTY
2 stops42h 28mUnited Airlines
Deal found 1/1R17 520
Wed 18/27:55PTY - JNB
2 stops27h 40mUnited Airlines
Sun 22/219:45JNB - PTY
2 stops41h 28mUnited Airlines
Deal found 3/1R17 520
Mon 13/49:13PTY - JNB
2 stops28h 17mUnited Airlines
Mon 20/419:00JNB - PTY
2 stops32h 41mUnited Airlines
Deal found 3/1R17 537
Mon 9/222:05PTY - JNB
2 stops31h 05mKLM
Tue 17/219:20JNB - PTY
2 stops31h 35mKLM
Deal found 3/1R17 636
Tue 7/418:50PTY - JNB
1 stop43h 30mKLM
Tue 9/623:15JNB - PTY
1 stop24h 35mKLM
Deal found 4/1R17 669

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 4 January 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

OR Tambo

Route

Depart

Return

Price

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 8/4

18:28-8:35

2 stops31h 07m

Johannesburg OR Tambo

Tue 16/6

19:00-8:49

2 stops44h 49m

R15 312

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 30/1

8:16-18:00

2 stops26h 44m

Cape Town Intl

Wed 4/2

20:50-20:35

2 stops30h 45m

R16 433

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 7/4

9:13-18:30

2 stops26h 17m

Johannesburg OR Tambo

Tue 9/6

22:00-14:22

2 stops47h 22m

R16 433

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 30/1

9:30-18:35

2 stops26h 05m

Johannesburg OR Tambo

Sat 7/2

22:00-20:27

2 stops29h 27m

R16 647

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 2/2

22:05-22:05

1 stop41h 00m

Johannesburg OR Tambo

Mon 9/2

19:20-20:10

1 stop31h 50m

R16 762

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 9/2

22:05-22:05

1 stop41h 00m

Johannesburg OR Tambo

Tue 17/2

19:20-16:30

2 stops28h 10m

R17 092

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 30/1

9:30-18:35

2 stops26h 05m

Johannesburg OR Tambo

Fri 6/2

19:45-6:13

2 stops41h 28m

R17 372

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 15/4

9:39-18:30

2 stops25h 51m

Johannesburg OR Tambo

Fri 15/5

19:00-20:41

2 stops32h 41m

R17 372

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

22:29-18:30

2 stops37h 01m

Johannesburg OR Tambo

Mon 20/4

19:00-20:41

2 stops32h 41m

R17 372

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 23/1

8:55-18:35

2 stops26h 40m

Johannesburg OR Tambo

Mon 26/1

19:45-6:37

2 stops41h 52m

R17 372

Flights are sorted by cheapest return flights first.

Deals found on 2/1

Showing 1-10 of 28 results
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

Which airlines fly from Panama?

When flying from Panama check dates and pricing for the following: United Airlines. As it departs for the following popular destinations: Johannesburg.

United Airlines
United Airlines
From R12 332

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 269. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 269
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 811
Madrid Barajas
Madrid Barajas
From R16 698

Airline reviews for flights from Panama

Get insights into the airlines that provide service from Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing airline for your flight from Panama. In the last 7 days, Cheapflights users made a total of 594 507 searches.
Get a feel of what it's like to fly with United Airlines from Panama by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7,4
Good
9 138 reviews
Check prices

Crew

8,1

Overall

7,4

Food

6,6

Comfort

7,3

Boarding

7,7

Entertainment

7,1

Reviews

1 / 20
10,0
Excellent

Anonymous,Sept 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.
United Airlines
7,4
Good
9 138 reviews
United Airlines
7,4
Good
9 138 reviews
Check prices

Crew

8,1

Overall

7,4

Food

6,6

Comfort

7,3

Boarding

7,7

Entertainment

7,1

Reviews

1 / 20
10,0
Excellent

Anonymous,Sept 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.

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Direct flights from Central America

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Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 4 January 2026.

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  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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