R3 609+ Cheap flights from Panama

This is the cheapest return flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 21/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — CPT
May 18 — May 251
1 adult
1 adult, Economy, 0 bags

Find flights from Panama within your budget

 
Find flights departing from Panama that match your specified budget. Filter results by price range, allowing you to narrow down options and find flights that fit within your financial constraints. Please note that the search results are based on data from user searches, with fares last updated on 18 April 2026. In the last 7 days, Cheapflights users made a total of 594 507 searches

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 21/9

8:10-18:30

2 stops27h 20m

Johannesburg OR Tambo

Tue 20/10

22:00-17:10

2 stops26h 10m

R17 178

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 6/5

8:11-18:30

2 stops27h 19m

Johannesburg OR Tambo

Tue 9/6

19:00-10:33

2 stops46h 33m

R17 227

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 10/6

8:11-8:35

2 stops41h 24m

Johannesburg OR Tambo

Wed 24/6

19:00-6:13

2 stops42h 13m

R18 158

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 1/6

8:11-8:35

2 stops41h 24m

Johannesburg OR Tambo

Mon 8/6

19:00-6:37

2 stops42h 37m

R18 158

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Thu 7/5

11:34-8:35

2 stops38h 01m

Johannesburg OR Tambo

Fri 12/6

19:00-10:33

2 stops46h 33m

R19 023

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 13/5

22:20-11:50

1 stop30h 30m

Cape Town Intl

Wed 20/5

16:35-18:30

2 stops32h 55m

R19 872

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 8/5

22:29-8:35

2 stops51h 06m

Johannesburg OR Tambo

Sun 7/6

15:05-20:35

2 stops36h 30m

R20 901

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 10/5

11:59-9:30

2 stops38h 31m

Cape Town Intl

Sun 24/5

17:55-13:31

2 stops50h 36m

R21 668

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 29/4

18:41-15:20

1 stop37h 39m

Cape Town Intl

Sun 31/5

17:55-20:35

2 stops33h 40m

R22 909

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 26/5

9:13-18:30

2 stops26h 17m

Johannesburg OR Tambo

Sat 6/6

19:00-20:35

2 stops32h 35m

R22 909

Flights are sorted by cheapest return flights first.

Deals found on 14/4

Showing 1-10 of 38 resultsSorted by cheapest first
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Best time to book a flight from Panama

Have a flexible travel schedule? Discover the best time to fly from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Panama

Get recent, data-driven insights about flights from Panama including ideal travel times, pricing trends, and more.

What is the cheapest place to fly to from Panama?

The cheapest city to fly to from Panama is Bogotá El Dorado, with prices starting at R1 257. Explore other affordable destinations below.

Bogotá El Dorado
Bogotá El Dorado
From R1 257
Panama City Tocumen Intl
Panama City Tocumen Intl
From R1 795
San José Juan Santamaria Intl
San José Juan Santamaria Intl
From R2 241
Madrid Barajas
Madrid Barajas
From R16 542

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Direct flights from Central America

Book a direct flight from one of these other cities located in Central America.
Direct flights from Panama City

Related info for your journey

Access useful and relevant information related to your journey from Panama. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 18 April 2026.

  • How does Cheapflights help users find flights from Panama?

    Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

  • Why should you use Cheapflights to find cheap flight tickets from Panama?

    It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

  • Can Cheapflights find flights from Panama with no change fees?

    Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

  • Can Cheapflights notify me if prices for flights from Panama become cheaper?

    Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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How does Cheapflights help users find flights from Panama?

Cheapflights helps you search for flights from Panama via 900+ travel sites so you don’t have to. After performing a flight search, users can also filter their flight selection by filtering for price, number of stops, airlines, and so on.

Why should you use Cheapflights to find cheap flight tickets from Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama.

Can Cheapflights find flights from Panama with no change fees?

Yes, we can. To see specific flights from Panama with no change fees, users can toggle flexible booking options after using the search form above to find flights.

Can Cheapflights notify me if prices for flights from Panama become cheaper?

Yes, Cheapflights has a feature called Price Alerts, which offers users the ability to be notified when flight prices change. Track prices for your flight from Panama today and book when you’re ready!

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