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Cheap flights from South Africa to Panama from R12 440

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
JNB — PTY
Feb 21 — Feb 281
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from South Africa to Panama

Enter your travel dates to find the best prices.

Cheapest flights from South Africa to Panama
Explore the most affordable flight options available from South Africa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 22 January 2026.

Fri 20/220:50
CPT
-
PTY
2 stops48h 55m
United Airlines
Sat 7/38:16
PTY
-
CPT
2 stops24h 54m
United Airlines
Deal found 20/1R18 937
Sun 8/37:55
CPT
-
PTY
1 stop43h 15m
Multiple Airlines
Sun 15/318:45
PTY
-
CPT
1 stop44h 10m
Multiple Airlines
Deal found 22/1R23 279
Sun 8/37:55
CPT
-
PTY
1 stop43h 15m
Air France
Sun 15/322:20
PTY
-
CPT
2 stops36h 00m
Air France
Deal found 22/1R23 475
Tue 20/122:00
JNB
-
PTY
2 stops29h 27m
United Airlines
Wed 24/622:29
PTY
-
JNB
2 stops37h 01m
United Airlines
Deal found 20/1R23 900
Tue 20/123:59
JNB
-
PTY
1 stop26h 56m
KLM
Wed 24/618:50
PTY
-
JNB
1 stop43h 45m
KLM
Deal found 20/1R25 467
Fri 20/214:35
CPT
-
PTY
3 stops33h 20m
Multiple Airlines
Sat 7/318:31
PTY
-
CPT
2 stops33h 29m
Multiple Airlines
Deal found 20/1R27 867
Fri 20/28:00
CPT
-
PTY
1 stop39h 30m
KLM
Sat 7/318:45
PTY
-
CPT
1 stop44h 10m
KLM
Deal found 20/1R28 814
Thu 21/519:50
CPT
-
PTY
2 stops27h 22m
United Airlines
Mon 25/59:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Deal found 19/1R30 511
Thu 21/519:00
JNB
-
PTY
2 stops32h 35m
United Airlines
Mon 25/59:13
PTY
-
JNB
2 stops26h 17m
United Airlines
Deal found 20/1R32 699
Tue 20/118:50
JNB
-
PTY
3 stops43h 46m
Multiple Airlines
Wed 24/612:00
PTY
-
JNB
2 stops39h 15m
Multiple Airlines
Deal found 20/1R82 915

Find flight deals from South Africa to Panama

Keep the following information in mind while searching for South Africa to Panama flight deals. Data was last updated 22 January 2026.

Round-trip from

R11 509

Popular in

December

Cheapest in

January

Average price

R18 823
5/3-11/3
  • 5/3-11/3
  • 4 total stops
  • 42h 40m total
  • South Africa to Panama
Search Deals
Highest demand for flights based on searches. 1% potential increase in price (R4 900 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (R4 927 potential savings vs. average return price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from South Africa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 22 January 2026.
Use the filters below to find and compare flights from South Africa to Panama that are best for you.

Fly from

South Africa

Fly to

Panama

Route

Depart

Return

Price

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Fri 20/2

20:50-14:45

2 stops48h 55m

Panama City Tocumen Intl

Sat 7/3

8:16-16:10

2 stops24h 54m

R18 937

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Sun 8/3

7:55-20:10

1 stop43h 15m

Panama City Tocumen Intl

Sun 15/3

18:45-21:55

1 stop44h 10m

R23 279

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Sun 8/3

7:55-20:10

1 stop43h 15m

Panama City Tocumen Intl

Sun 15/3

22:20-17:20

2 stops36h 00m

R23 475

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Fri 20/2

14:35-16:55

3 stops33h 20m

Panama City Tocumen Intl

Sat 7/3

18:31-11:00

2 stops33h 29m

R27 867

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Fri 20/2

8:00-16:30

1 stop39h 30m

Panama City Tocumen Intl

Sat 7/3

18:45-21:55

1 stop44h 10m

R28 814

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Thu 21/5

19:50-16:12

2 stops27h 22m

Panama City Tocumen Intl

Mon 25/5

9:13-15:20

1 stop23h 07m

R30 511

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Thu 21/5

19:00-20:35

2 stops32h 35m

Panama City Tocumen Intl

Mon 25/5

9:13-18:30

2 stops26h 17m

R32 699

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Tue 10/2

15:30-14:00

2 stops29h 30m

R12 440

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Wed 11/2

22:30-0:40

3 stops57h 10m

R14 072

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Mon 9/2

20:30-19:50

3 stops54h 20m

R15 541

Flights are sorted by cheapest return flights first.

Deals found on 22/1

Showing 1-10 of 12 results
1
2

Best time to book a flight from South Africa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Africa with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Africa to Panama

What is the cheapest month to book a flight from South Africa to Panama?

Currently, August is the cheapest month in which you can book a flight from South Africa to Panama (average of R7 754). Flying from South Africa to Panama in September is currently the most expensive (average of R20 635). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated 22 January 2026.
Check out reviews from past customers who have flown with KLM, Air France, andUnited Airlines from South Africa to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7,7
Good
1 442 reviews
Check prices

Food

7,3

Boarding

7,8

Entertainment

7,1

Comfort

7,6

Crew

8,4

Overall

7,7

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
KLM
7,7
Good
1 442 reviews
KLM
7,7
Good
1 442 reviews
Check prices

Food

7,3

Boarding

7,8

Entertainment

7,1

Comfort

7,6

Crew

8,4

Overall

7,7

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
Air France
7,4
Good
1 523 reviews
KLM
7,7
Good
1 442 reviews
Check prices

Food

7,3

Boarding

7,8

Entertainment

7,1

Comfort

7,6

Crew

8,4

Overall

7,7

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
United Airlines
7,4
Good
9 191 reviews
KLM
7,7
Good
1 442 reviews
Check prices

Food

7,3

Boarding

7,8

Entertainment

7,1

Comfort

7,6

Crew

8,4

Overall

7,7

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
British Airways
6,7
Okay
7 689 reviews
KLM
7,7
Good
1 442 reviews
Check prices

Food

7,3

Boarding

7,8

Entertainment

7,1

Comfort

7,6

Crew

8,4

Overall

7,7

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.

Related info for your journey

Find useful and relevant information for your journey from South Africa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Africa to Panama?

    For as low as R23 475, United Airlines can have you in Panama from South Africa in 43h 15m. Airlines will cover a distance of 11294 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from South Africa to Panama that include hotel bookings?

    Yes. In addition to deals on South Africa to Panama flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from South Africa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Africa to Panama.

  • Can I find deals for business class flights from South Africa to Panama?

    Yes. Cheapflights offers flight deals from South Africa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Africa to Panama?

    Currently, August is the cheapest month in which you can book a flight from South Africa to Panama (average of R7 754). Flying from South Africa to Panama in September is currently the most expensive (average of R20 635). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Africa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Cape Town to San José flights
OR Tambo to Panama City flights
Cape Town to Panama City flights
OR Tambo to San José flights
Cape Town to Guatemala City flights
OR Tambo to Liberia flights

Top 4 airlines flying from South Africa to Panama

Discover the top 4 airlines that operate flights from South Africa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 22 January 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapestR17 186AverageR21 095FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
British AirwaysCheapestR18 149AverageR21 341FlexibilityNo cancel feeOn-time70%
Search British Airways flights
KLMCheapestR22 005AverageR25 283FlexibilityNo cancel feeOn-time75%
Search KLM flights
Air FranceCheapestR22 722AverageR24 847FlexibilityNo cancel feeOn-time77%
Search Air France flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from South Africa to Panama?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to Panama from South Africa today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from South Africa to Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from South Africa to Panama.

Can Cheapflights find flights from South Africa to Panama with no change fees?

Need flexible booking options for your flight to Panama from South Africa? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from South Africa to Panama become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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