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Cheap flights from South Africa to Panama from R10 113

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/3. Fares are subject to change and may not be available on all flights or dates of travel.
JNB — PTY
Mar 3 — Mar 101
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from South Africa to Panama

Enter your travel dates to find the best prices.

Cheapest flights from South Africa to Panama
Explore the most affordable flight options available from South Africa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 1 February 2026.

Wed 11/322:00
JNB
-
PTY
2 stops45h 40m
American Airlines
Wed 18/313:40
PTY
-
JNB
2 stops34h 55m
American Airlines
Deal found 1/2R21 979
Tue 17/37:00
CPT
-
PTY
3 stops38h 00m
Multiple Airlines
Tue 24/318:31
PTY
-
CPT
2 stops33h 29m
Multiple Airlines
Deal found 31/1R24 535
Wed 11/323:59
JNB
-
PTY
1 stop23h 31m
KLM
Wed 18/318:45
PTY
-
JNB
1 stop44h 20m
KLM
Deal found 1/2R25 371
Tue 17/314:00
CPT
-
PTY
2 stops33h 30m
KLM
Tue 24/318:45
PTY
-
CPT
1 stop44h 10m
KLM
Deal found 31/1R29 310
Thu 21/519:50
CPT
-
PTY
2 stops28h 20m
United Airlines
Mon 25/59:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Deal found 31/1R29 664
Thu 21/519:00
JNB
-
PTY
2 stops32h 35m
United Airlines
Mon 25/522:29
PTY
-
JNB
2 stops37h 01m
United Airlines
Deal found 30/1R30 243
Thu 21/513:00
CPT
-
PTY
2 stops38h 00m
Qatar Airways
Mon 25/513:10
PTY
-
CPT
2 stops39h 20m
Qatar Airways
Deal found 31/1R39 439

Find flight deals from South Africa to Panama

Keep the following information in mind while searching for South Africa to Panama flight deals. Data was last updated 1 February 2026.

Round-trip from

R21 979

One-way from

R10 113

Popular in

December

Cheapest in

January

Average price

R21 094
American Airlines
  • American Airlines
  • 11/3-18/3
  • 4 total stops
  • 80h 35m total
  • South Africa to Panama
Search Deals
15/3
  • 15/3
  • 3 total stops
  • 31h 10m total
  • South Africa to Panama
Search Deals
Highest demand for flights based on searches. 1% potential increase in price (R4 392 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (R4 740 potential savings vs. average return price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from South Africa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 1 February 2026.
Use the filters below to find and compare flights from South Africa to Panama that are best for you.

Fly from

South Africa

Fly to

Panama

Route

Depart

Return

Price

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Wed 11/3

22:00-12:40

2 stops45h 40m

Panama City Tocumen Intl

Wed 18/3

13:40-7:35

2 stops34h 55m

R21 979

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Tue 17/3

7:00-14:00

3 stops38h 00m

Panama City Tocumen Intl

Tue 24/3

18:31-11:00

2 stops33h 29m

R24 535

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Wed 11/3

23:59-16:30

1 stop23h 31m

Panama City Tocumen Intl

Wed 18/3

18:45-22:05

1 stop44h 20m

R25 371

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Tue 17/3

14:00-16:30

2 stops33h 30m

Panama City Tocumen Intl

Tue 24/3

18:45-21:55

1 stop44h 10m

R29 310

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Thu 21/5

19:50-17:10

2 stops28h 20m

Panama City Tocumen Intl

Mon 25/5

9:13-15:20

1 stop23h 07m

R29 664

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Thu 21/5

19:00-20:35

2 stops32h 35m

Panama City Tocumen Intl

Mon 25/5

22:29-18:30

2 stops37h 01m

R30 243

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Thu 21/5

13:00-20:00

2 stops38h 00m

Panama City Tocumen Intl

Mon 25/5

13:10-11:30

2 stops39h 20m

R39 439

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Sun 15/3

0:30-0:40

3 stops31h 10m

R10 113

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Tue 21/4

0:30-14:15

3 stops44h 45m

R11 351

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Tue 30/6

0:30-1:05

3 stops31h 35m

R11 383

Flights are sorted by cheapest return flights first.

Deals found on 1/2

Showing 1-10 of 14 results
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Best time to book a flight from South Africa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Africa with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Africa to Panama

What is the cheapest month to book a flight from South Africa to Panama?

Currently, August is the cheapest month in which you can book a flight from South Africa to Panama (average of R7 637). Flying from South Africa to Panama in September is currently the most expensive (average of R20 323). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated 1 February 2026.
Check out reviews from past customers who have flown with KLM, Air France, andUnited Airlines from South Africa to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7,7
Good
1 446 reviews
Check prices

Boarding

7,8

Food

7,3

Overall

7,7

Comfort

7,6

Entertainment

7,1

Crew

8,4

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
KLM
7,7
Good
1 446 reviews
KLM
7,7
Good
1 446 reviews
Check prices

Boarding

7,8

Food

7,3

Overall

7,7

Comfort

7,6

Entertainment

7,1

Crew

8,4

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
Air France
7,4
Good
1 531 reviews
KLM
7,7
Good
1 446 reviews
Check prices

Boarding

7,8

Food

7,3

Overall

7,7

Comfort

7,6

Entertainment

7,1

Crew

8,4

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
United Airlines
7,4
Good
9 229 reviews
KLM
7,7
Good
1 446 reviews
Check prices

Boarding

7,8

Food

7,3

Overall

7,7

Comfort

7,6

Entertainment

7,1

Crew

8,4

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.
British Airways
6,7
Okay
7 709 reviews
KLM
7,7
Good
1 446 reviews
Check prices

Boarding

7,8

Food

7,3

Overall

7,7

Comfort

7,6

Entertainment

7,1

Crew

8,4

Reviews

1 / 20
10,0
Excellent

Snapyou,Jan 2026

TPA - LHR

Flight operated by Virgin Atlantic - usual high standard service by Virgin.

Related info for your journey

Find useful and relevant information for your journey from South Africa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Africa to Panama?

    For as low as R25 371, American Airlines can have you in Panama from South Africa in 23h 31m. Airlines will cover a distance of 12194 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from South Africa to Panama that include hotel bookings?

    Yes. In addition to deals on South Africa to Panama flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from South Africa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Africa to Panama.

  • Can I find deals for business class flights from South Africa to Panama?

    Yes. Cheapflights offers flight deals from South Africa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Africa to Panama?

    Currently, August is the cheapest month in which you can book a flight from South Africa to Panama (average of R7 637). Flying from South Africa to Panama in September is currently the most expensive (average of R20 323). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Africa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
OR Tambo to Panama City flights
OR Tambo to San José flights
Cape Town to Guatemala City flights
Cape Town to Panama City flights
Cape Town to San José flights
OR Tambo to Liberia flights

Top 4 airlines flying from South Africa to Panama

Discover the top 4 airlines that operate flights from South Africa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 1 February 2026.
AirlineCheapestAverageFlexibilityOn-time
British AirwaysCheapestR17 875AverageR21 095FlexibilityNo cancel feeOn-time70%
Search British Airways flights
United AirlinesCheapestR18 179AverageR20 953FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
KLMCheapestR21 672AverageR24 909FlexibilityNo cancel feeOn-time75%
Search KLM flights
Air FranceCheapestR23 309AverageR24 471FlexibilityNo cancel feeOn-time77%
Search Air France flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from South Africa to Panama?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to Panama from South Africa today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from South Africa to Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from South Africa to Panama.

Can Cheapflights find flights from South Africa to Panama with no change fees?

Need flexible booking options for your flight to Panama from South Africa? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from South Africa to Panama become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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