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Cheap flights from South Africa to Panama from R12 979

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 25/4. Fares are subject to change and may not be available on all flights or dates of travel.
JNB — PTY
Apr 22 — Apr 291
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from South Africa to Panama

Enter your travel dates to find the best prices.

Cheapest flights from South Africa to Panama
Explore the most affordable flight options available from South Africa to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 23 March 2026.

Thu 7/519:25
JNB
-
PTY
2 stops48h 21m
American Airlines
Thu 14/513:49
PTY
-
JNB
2 stops34h 11m
American Airlines
Deal found 23/3R22 481
Thu 7/514:45
JNB
-
PTY
3 stops33h 15m
Multiple Airlines
Thu 14/518:31
PTY
-
JNB
2 stops31h 04m
Multiple Airlines
Deal found 23/3R23 159
Sun 3/522:00
JNB
-
PTY
2 stops27h 37m
United Airlines
Sun 10/57:55
PTY
-
JNB
2 stops27h 35m
United Airlines
Deal found 19/3R24 313
Tue 21/410:25
JNB
-
PTY
2 stops50h 48m
United Airlines
Thu 11/67:55
PTY
-
JNB
2 stops27h 35m
United Airlines
Deal found 21/3R25 009
Mon 4/57:40
CPT
-
PTY
1 stop40h 10m
KLM
Mon 11/518:50
PTY
-
CPT
1 stop43h 35m
KLM
Deal found 20/3R26 892
Tue 21/410:25
JNB
-
PTY
2 stops50h 48m
United Airlines
Mon 15/69:13
PTY
-
JNB
2 stops26h 17m
United Airlines
Deal found 21/3R27 044
Mon 4/513:00
CPT
-
PTY
3 stops42h 35m
Multiple Airlines
Mon 11/54:25
PTY
-
CPT
3 stops48h 05m
Multiple Airlines
Deal found 20/3R27 129
Mon 8/620:40
JNB
-
PTY
2 stops54h 20m
Multiple Airlines
Mon 22/613:14
PTY
-
JNB
2 stops37h 11m
Multiple Airlines
Deal found 23/3R27 248
Tue 21/419:25
JNB
-
PTY
2 stops31h 35m
British Airways
Fri 12/621:30
PTY
-
JNB
2 stops52h 55m
British Airways
Deal found 21/3R27 265
Wed 22/421:15
JNB
-
PTY
2 stops53h 45m
British Airways
Sun 14/621:30
PTY
-
JNB
2 stops28h 55m
British Airways
Deal found 21/3R27 418
Wed 22/421:15
JNB
-
PTY
2 stops53h 45m
British Airways
Wed 10/621:30
PTY
-
JNB
2 stops28h 55m
British Airways
Deal found 21/3R27 435
Fri 5/619:25
JNB
-
PTY
2 stops55h 35m
British Airways
Sun 28/621:05
PTY
-
JNB
2 stops26h 55m
British Airways
Deal found 21/3R27 706

Find flight deals from South Africa to Panama

Keep the following information in mind while searching for South Africa to Panama flight deals. Data was last updated 23 March 2026.

Round-trip from

R22 481

One-way from

R12 979

Popular in

December

Cheapest in

February

Average price

R23 821
American Airlines
  • American Airlines
  • 7/5-14/5
  • 4 total stops
  • 82h 32m total
  • South Africa to Panama
Search Deals
25/4
  • 25/4
  • 3 total stops
  • 56h 30m total
  • South Africa to Panama
Search Deals
Highest demand for flights based on searches. 4% potential increase in price (R18 308 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease (R4 852 potential savings vs. average return price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from South Africa to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 23 March 2026.
Use the filters below to find and compare flights from South Africa to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Thu 7/5

19:25-12:46

2 stops48h 21m

Panama City Tocumen Intl

Thu 14/5

13:49-7:00

2 stops34h 11m

R22 481

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Sun 3/5

22:00-18:37

2 stops27h 37m

Panama City Tocumen Intl

Sun 10/5

7:55-18:30

2 stops27h 35m

R24 313

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Mon 4/5

15:20-16:50

2 stops32h 30m

Panama City Tocumen Intl

Mon 11/5

18:50-21:25

1 stop43h 35m

R27 078

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Thu 7/5

23:15-19:45

2 stops51h 30m

Panama City Tocumen Intl

Thu 14/5

18:50-21:20

1 stop43h 30m

R28 249
Fastest return journey

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Mon 1/6

23:15-16:50

1 stop24h 35m

Panama City Tocumen Intl

Mon 15/6

21:55-11:05

1 stop30h 10m

R28 385

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Tue 2/6

23:15-16:50

1 stop24h 35m

Panama City Tocumen Intl

Sat 6/6

18:50-21:20

1 stop43h 30m

R28 385

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Fri 1/5

23:45-16:50

2 stops48h 05m

Panama City Tocumen Intl

Fri 15/5

18:50-21:25

1 stop43h 35m

R28 894

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Fri 5/6

23:15-16:50

1 stop24h 35m

Panama City Tocumen Intl

Sun 28/6

18:50-11:05

2 stops33h 15m

R28 928

JohannesburgPanama City

JNB - PTY

JNBPTY

Johannesburg OR Tambo

Tue 2/6

21:15-20:00

2 stops29h 45m

Panama City Tocumen Intl

Sat 6/6

13:14-9:25

2 stops37h 11m

R28 979

Cape TownPanama City

CPT - PTY

CPTPTY

Cape Town Intl

Fri 1/5

23:15-16:50

1 stop24h 35m

Panama City Tocumen Intl

Fri 15/5

18:50-21:25

1 stop43h 35m

R30 031

Flights are sorted by cheapest return flights first.

Deals found on 20/3

Showing 1-10 of 29 resultsSorted by cheapest first
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Best time to book a flight from South Africa to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Africa with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Africa to Panama

What is the cheapest month to book a flight from South Africa to Panama?

Currently, August is the cheapest month in which you can book a flight from South Africa to Panama (average of R8 059). Flying from South Africa to Panama in September is currently the most expensive (average of R21 157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated 23 March 2026.
Check out reviews from past customers who have flown with KLM,Air France, andUnited Airlines from South Africa to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7,8
Good
1 477 reviews
Check prices

Food

7,3

Boarding

7,8

Comfort

7,6

Crew

8,4

Entertainment

7,1

Overall

7,8

Reviews

1 / 20
2,0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
KLM
7,8
Good
1 477 reviews
KLM
7,8
Good
1 477 reviews
Check prices

Food

7,3

Boarding

7,8

Comfort

7,6

Crew

8,4

Entertainment

7,1

Overall

7,8

Reviews

1 / 20
2,0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
Air France
7,4
Good
1 547 reviews
KLM
7,8
Good
1 477 reviews
Check prices

Food

7,3

Boarding

7,8

Comfort

7,6

Crew

8,4

Entertainment

7,1

Overall

7,8

Reviews

1 / 20
2,0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
United Airlines
7,4
Good
9 465 reviews
KLM
7,8
Good
1 477 reviews
Check prices

Food

7,3

Boarding

7,8

Comfort

7,6

Crew

8,4

Entertainment

7,1

Overall

7,8

Reviews

1 / 20
2,0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas
British Airways
6,7
Okay
7 812 reviews
KLM
7,8
Good
1 477 reviews
Check prices

Food

7,3

Boarding

7,8

Comfort

7,6

Crew

8,4

Entertainment

7,1

Overall

7,8

Reviews

1 / 20
2,0
Mediocre

Anonymous,Feb 2026

EZE - SCL

It was a short trip The aeroplane was delay I arrived in Chile late and I lost my fly with Qantas

Related info for your journey

Find useful and relevant information for your journey from South Africa to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Africa to Panama?

    For as low as R24 313, American Airlines can have you in Panama from South Africa in 27h 37m. Airlines will cover a distance of 12194 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from South Africa to Panama that include hotel bookings?

    Yes. In addition to deals on South Africa to Panama flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from South Africa to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Africa to Panama.

  • Can I find deals for business class flights from South Africa to Panama?

    Yes. Cheapflights offers flight deals from South Africa to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Africa to Panama?

    Currently, August is the cheapest month in which you can book a flight from South Africa to Panama (average of R8 059). Flying from South Africa to Panama in September is currently the most expensive (average of R21 157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Africa to Panama

See prices for flight routes from nearby airports that may be better suited for you.
OR Tambo to Panama City flights
OR Tambo to San José flights
Cape Town to San José flights
Cape Town to Guatemala City flights
Cape Town to Panama City flights
OR Tambo to Liberia flights

Top 4 airlines flying from South Africa to Panama

Discover the top 4 airlines that operate flights from South Africa to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 23 March 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapestR19 431AverageR22 010FlexibilityNo cancel feeOn-time69%
Search United Airlines flights
British AirwaysCheapestR19 523AverageR21 805FlexibilityNo cancel feeOn-time70%
Search British Airways flights
KLMCheapestR23 739AverageR27 035FlexibilityNo cancel feeOn-time75%
Search KLM flights
Air FranceCheapestR24 597AverageR25 859FlexibilityNo cancel feeOn-time77%
Search Air France flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from South Africa to Panama?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to Panama from South Africa today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from South Africa to Panama?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from South Africa to Panama.

Can Cheapflights find flights from South Africa to Panama with no change fees?

Need flexible booking options for your flight to Panama from South Africa? Don’t worry, Cheapflights have you covered. Use our search filter to only show flights with no change fees.

Can Cheapflights notify me if prices for flights from South Africa to Panama become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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