Cheap flights from Panama to South Africa from R16 323

PTY — JNB
Nov 29 — Dec 61
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa

Thu 26/1110:00 -
1 stop25h 35m
Thu 3/1219:45 -
2 stops31h 56m
Deal found 29/10R17 220
Thu 5/1118:48 -
2 stops62h 22m
Mon 30/1119:10 -
2 stops42h 03m
Deal found 28/10R20 777
Thu 5/1122:30 -
1 stop24h 55m
Mon 30/118:30 -
2 stops39h 00m
Deal found 26/10R22 124
Mon 23/1110:00 -
1 stop25h 35m
Fri 27/1122:00 -
2 stops43h 33m
Deal found 29/10R23 586
Thu 26/1121:30 -
1 stop30h 10m
Thu 3/1219:55 -
1 stop30h 50m
Deal found 29/10R26 213
Tue 15/1218:30 -
2 stops32h 10m
Tue 29/1219:45 -
2 stops41h 54m
Deal found 26/10R34 590
Tue 15/1221:30 -
1 stop30h 10m
Tue 29/1219:55 -
1 stop30h 50m
Deal found 26/10R35 188
Thu 26/1121:30 -
3 stops34h 10m
Thu 3/1216:40 -
3 stops34h 05m
Deal found 29/10R35 205
Thu 5/1118:50 -
2 stops39h 30m
Mon 30/1114:00 -
3 stops34h 10m
Deal found 26/10R61 617

Find flight deals from Panama to South Africa

Round-trip from

R16 323

Popular in

June

Cheapest in

May

Average price

R21 076
United Airlines
  • United Airlines
  • 14/1-29/1
  • 3 total stops
  • 104h 52m total
  • Panama to South Africa
Highest demand for flights based on searches. 10% potential increase in price (R44 338 potential increase over avg. return price).
Cheapest flight prices on average. 5% potential price decrease (R18 958 potential savings vs. average return price).
Average for round-trip flights in October 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

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Route

Depart

Return

Price

Cheapest return flight

Panama CityCape Town

PTY Panama City Tocumen Intl - CPT Cape Town Intl

PTYCPT

Panama City Tocumen Intl

Tue 12/1

16:41-18:00

2 stops42h 19m

Cape Town Intl

Tue 26/1

20:50-6:37

2 stops40h 47m

R16 323

Panama CityCape Town

PTY Panama City Tocumen Intl - CPT Cape Town Intl

PTYCPT

Panama City Tocumen Intl

Thu 14/1

16:41-16:10

2 stops64h 29m

Cape Town Intl

Sun 31/1

20:50-13:31

1 stop23h 41m

R16 323

Panama CityCape Town

PTY Panama City Tocumen Intl - CPT Cape Town Intl

PTYCPT

Panama City Tocumen Intl

Mon 18/1

16:41-18:00

2 stops42h 19m

Cape Town Intl

Tue 2/2

20:50-20:35

1 stop30h 45m

R16 323

Panama CityJohannesburg

PTY Panama City Tocumen Intl - JNB Johannesburg OR Tambo

PTYJNB

Panama City Tocumen Intl

Mon 1/2

10:00-18:35

1 stop25h 35m

Johannesburg OR Tambo

Tue 16/2

22:00-20:02

1 stop29h 02m

R16 323

Panama CityJohannesburg

PTY Panama City Tocumen Intl - JNB Johannesburg OR Tambo

PTYJNB

Panama City Tocumen Intl

Mon 1/2

10:00-18:35

1 stop25h 35m

Johannesburg OR Tambo

Mon 15/2

22:00-20:36

2 stops29h 36m

R16 472

Panama CityJohannesburg

PTY Panama City Tocumen Intl - JNB Johannesburg OR Tambo

PTYJNB

Panama City Tocumen Intl

Sun 24/1

10:00-18:35

1 stop25h 35m

Johannesburg OR Tambo

Sat 30/1

19:45-1:20

2 stops36h 35m

R16 605

Panama CityJohannesburg

PTY Panama City Tocumen Intl - JNB Johannesburg OR Tambo

PTYJNB

Panama City Tocumen Intl

Thu 26/11

10:00-18:35

1 stop25h 35m

Johannesburg OR Tambo

Thu 3/12

19:45-20:41

2 stops31h 56m

R17 220

Panama CityJohannesburg

PTY Panama City Tocumen Intl - JNB Johannesburg OR Tambo

PTYJNB

Panama City Tocumen Intl

Fri 29/1

10:00-18:35

1 stop25h 35m

Johannesburg OR Tambo

Wed 14/4

19:00-16:12

2 stops52h 12m

R17 336

Panama CityJohannesburg

PTY Panama City Tocumen Intl - JNB Johannesburg OR Tambo

PTYJNB

Panama City Tocumen Intl

Sat 9/1

21:48-10:40

2 stops53h 52m

Johannesburg OR Tambo

Wed 31/12

0:00-17:00

Nonstop0h 00m

R17 785

Panama CityJohannesburg

PTY Panama City Tocumen Intl - JNB Johannesburg OR Tambo

PTYJNB

Panama City Tocumen Intl

Sun 31/1

10:00-18:35

1 stop25h 35m

Johannesburg OR Tambo

Sat 6/2

19:45-6:35

2 stops41h 50m

R18 384

Flights are sorted by cheapest return flights first.

Deals found on 28/10

Showing 1-10 of 27 resultsSorted by cheapest first
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, July is the cheapest month in which you can book a flight from Panama to South Africa (average of R16 256). Flying from Panama to South Africa in November is currently the most expensive (average of R26 744). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

  • How long is the flight from Panama to South Africa?

    For as low as R16 323, United Airlines can have you in South Africa from Panama in 42h 19m. The distance from Panama to South Africa is about 11294 km.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, July is the cheapest month in which you can book a flight from Panama to South Africa (average of R16 256). Flying from Panama to South Africa in November is currently the most expensive (average of R26 744). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama to South Africa

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Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

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