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Cheap flights from Panama to South Africa from R9 131

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 26/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JNB
May 28 — Jun 41
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa
Explore the most affordable flight options available from Panama to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 April 2026.

Sun 4/109:45
PTY
-
CPT
2 stops43h 55m
United Airlines
Tue 10/1120:50
CPT
-
PTY
1 stop30h 45m
United Airlines
Deal found 27/4R15 421
Sun 4/109:45
PTY
-
CPT
2 stops43h 55m
United Airlines
Sun 8/1120:50
CPT
-
PTY
1 stop30h 45m
United Airlines
Deal found 27/4R16 049
Fri 23/109:45
PTY
-
JNB
1 stop25h 45m
United Airlines
Sun 8/1119:45
JNB
-
PTY
2 stops31h 50m
United Airlines
Deal found 26/4R16 181
Wed 7/109:45
PTY
-
CPT
2 stops48h 35m
United Airlines
Wed 21/1017:55
CPT
-
PTY
2 stops33h 40m
United Airlines
Deal found 26/4R16 362
Mon 5/109:45
PTY
-
CPT
2 stops43h 55m
United Airlines
Mon 9/1120:50
CPT
-
PTY
1 stop30h 12m
United Airlines
Deal found 27/4R16 660
Sat 3/109:45
PTY
-
CPT
2 stops43h 55m
United Airlines
Tue 10/1120:50
CPT
-
PTY
2 stops30h 12m
United Airlines
Deal found 27/4R16 924
Mon 5/109:45
PTY
-
CPT
2 stops48h 35m
United Airlines
Fri 6/1118:45
CPT
-
PTY
2 stops42h 28m
United Airlines
Deal found 27/4R16 973
Sun 4/109:45
PTY
-
CPT
2 stops43h 55m
United Airlines
Sat 7/119:30
CPT
-
PTY
2 stops41h 32m
United Airlines
Deal found 27/4R16 990
Wed 6/58:11
PTY
-
JNB
2 stops27h 19m
United Airlines
Fri 29/519:00
JNB
-
PTY
2 stops40h 04m
United Airlines
Deal found 24/4R17 419
Sat 3/109:45
PTY
-
CPT
2 stops48h 35m
United Airlines
Sun 8/1120:50
CPT
-
PTY
3 stops30h 37m
United Airlines
Deal found 27/4R17 551
Mon 5/109:45
PTY
-
CPT
2 stops43h 55m
United Airlines
Sat 7/119:30
CPT
-
PTY
2 stops41h 32m
United Airlines
Deal found 27/4R17 601
Fri 30/1019:40
PTY
-
CPT
2 stops63h 20m
United Airlines
Sat 7/119:30
CPT
-
PTY
2 stops41h 32m
United Airlines
Deal found 26/4R17 683

Find flight deals from Panama to South Africa

Keep the following information in mind while searching for Panama to South Africa flight deals. Data was last updated 28 April 2026.

Round-trip from

R15 421

One-way from

R9 131

Popular in

December

Cheapest in

March

Average price

R20 573
United Airlines
  • United Airlines
  • 4/10-10/11
  • 3 total stops
  • 74h 40m total
  • Panama to South Africa
Search Deals
United Airlines
  • United Airlines
  • 27/9
  • 1 total stop
  • 24h 25m total
  • Panama to South Africa
Search Deals
Highest demand for flights based on searches. 18% potential increase in price (R94 583 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease (R29 398 potential savings vs. average return price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama to South Africa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 28 April 2026.
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 23/10

9:39-18:30

2 stops25h 51m

Johannesburg OR Tambo

Sun 8/11

19:45-6:13

2 stops41h 28m

R16 181

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 7/10

9:45-17:20

2 stops48h 35m

Cape Town Intl

Wed 21/10

17:55-5:33

2 stops42h 38m

R16 362

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 2/9

19:25-17:10

2 stops62h 45m

Cape Town Intl

Wed 16/9

17:55-20:34

2 stops33h 39m

R20 953

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 4/8

7:55-18:30

2 stops27h 35m

Johannesburg OR Tambo

Tue 3/11

19:45-10:24

2 stops45h 39m

R20 953

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 13/5

9:45-18:30

1 stop25h 45m

Johannesburg OR Tambo

Sun 17/5

19:00-13:31

2 stops49h 31m

R21 184

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sat 15/8

22:55-18:30

1 stop36h 35m

Johannesburg OR Tambo

Sat 22/8

19:00-20:35

2 stops32h 35m

R22 273

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 10/5

9:13-9:30

2 stops41h 17m

Cape Town Intl

Sun 24/5

17:55-13:31

2 stops50h 36m

R22 736

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 10/5

18:50-21:25

1 stop43h 35m

Cape Town Intl

Sun 24/5

23:15-19:45

2 stops27h 30m

R36 886

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 2/9

18:50-21:25

1 stop43h 35m

Cape Town Intl

Wed 16/9

7:40-16:50

1 stop40h 10m

R38 058
Cheapest one-way
Fastest single journey

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 27/9

9:45-17:10

1 stop24h 25m

R9 131

Flights are sorted by cheapest return flights first.

Deals found on 28/4

Showing 1-10 of 18 resultsSorted by cheapest first
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 350). Flying from Panama to South Africa in December is currently the most expensive (average of R37 266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Africa?

    For as low as R16 181, United Airlines can have you in South Africa from Panama in 25h 51m. The distance from Panama to South Africa is about 12194 km.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 350). Flying from Panama to South Africa in December is currently the most expensive (average of R37 266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Africa

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Cape Town flights
Panama City to OR Tambo flights
San José to OR Tambo flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama to South Africa?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to South Africa from Panama today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Panama to South Africa?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama to South Africa.

Can Cheapflights find flights from Panama to South Africa with no change fees?

Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama to South Africa become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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