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Cheap flights from Panama to South Africa from R9 121

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JNB
May 14 — May 211
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa
Explore the most affordable flight options available from Panama to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 14 April 2026.

Sun 1/119:45
PTY
-
JNB
3 stops41h 45m
Multiple Airlines
Sun 8/1119:45
JNB
-
PTY
2 stops44h 05m
Multiple Airlines
Deal found 9/4R16 444
Mon 21/99:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Mon 2/1120:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 13/4R16 626
Sun 20/917:51
PTY
-
CPT
2 stops38h 29m
United Airlines
Wed 28/1020:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 13/4R16 692
Mon 18/511:25
PTY
-
JNB
3 stops38h 55m
Multiple Airlines
Tue 2/619:00
JNB
-
PTY
2 stops42h 48m
Multiple Airlines
Deal found 12/4R17 121
Sun 20/99:13
PTY
-
JNB
2 stops26h 17m
United Airlines
Tue 20/1022:00
JNB
-
PTY
2 stops43h 33m
United Airlines
Deal found 13/4R17 351
Sun 3/519:25
PTY
-
JNB
2 stops40h 05m
United Airlines
Tue 9/619:00
JNB
-
PTY
2 stops46h 33m
United Airlines
Deal found 13/4R17 401
Sat 19/922:29
PTY
-
CPT
2 stops35h 41m
United Airlines
Wed 28/1020:50
CPT
-
PTY
2 stops28h 48m
United Airlines
Deal found 13/4R17 467
Mon 21/99:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Sat 31/1020:50
CPT
-
PTY
2 stops27h 18m
United Airlines
Deal found 13/4R17 500
Mon 21/99:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Tue 27/1018:45
CPT
-
PTY
2 stops49h 48m
United Airlines
Deal found 13/4R18 242
Tue 26/522:29
PTY
-
JNB
2 stops37h 01m
United Airlines
Tue 9/619:00
JNB
-
PTY
2 stops32h 34m
United Airlines
Deal found 12/4R18 292
Sun 20/919:25
PTY
-
CPT
2 stops36h 55m
United Airlines
Tue 27/1018:45
CPT
-
PTY
2 stops49h 48m
United Airlines
Deal found 13/4R18 325
Sun 20/99:39
PTY
-
JNB
2 stops25h 51m
United Airlines
Wed 28/1019:45
JNB
-
PTY
2 stops48h 48m
United Airlines
Deal found 13/4R18 325

Find flight deals from Panama to South Africa

Keep the following information in mind while searching for Panama to South Africa flight deals. Data was last updated 14 April 2026.

Round-trip from

R16 626

One-way from

R9 121

Popular in

December

Cheapest in

March

Average price

R20 551
United Airlines
  • United Airlines
  • 21/9-2/11
  • 3 total stops
  • 53h 52m total
  • Panama to South Africa
Search Deals
United Airlines
  • United Airlines
  • 24/4
  • 2 total stops
  • 46h 41m total
  • Panama to South Africa
Search Deals
Highest demand for flights based on searches. 18% potential increase in price (R94 384 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease (R29 336 potential savings vs. average return price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama to South Africa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 14 April 2026.
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 21/9

8:10-18:30

2 stops27h 20m

Johannesburg OR Tambo

Tue 20/10

22:00-17:10

2 stops26h 10m

R17 351

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 20/9

9:13-18:30

2 stops26h 17m

Johannesburg OR Tambo

Tue 20/10

22:00-10:33

2 stops43h 33m

R17 351

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 6/5

8:11-18:30

2 stops27h 19m

Johannesburg OR Tambo

Tue 9/6

19:00-10:33

2 stops46h 33m

R17 401

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 21/9

8:10-18:30

2 stops27h 20m

Johannesburg OR Tambo

Wed 28/10

19:45-13:33

2 stops48h 48m

R18 325

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 8/6

12:04-8:35

2 stops37h 31m

Johannesburg OR Tambo

Tue 23/6

19:00-6:13

2 stops42h 13m

R18 341

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Tue 9/6

9:12-8:35

2 stops40h 23m

Johannesburg OR Tambo

Tue 23/6

19:00-6:13

2 stops42h 13m

R18 341

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 24/5

11:59-8:35

2 stops37h 36m

Johannesburg OR Tambo

Tue 9/6

19:00-20:34

2 stops32h 34m

R19 215

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Thu 7/5

11:34-8:35

2 stops38h 01m

Johannesburg OR Tambo

Fri 12/6

19:00-10:33

2 stops46h 33m

R19 215

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 1/7

9:39-9:30

2 stops40h 51m

Cape Town Intl

Sun 27/9

20:00-17:10

2 stops28h 10m

R20 931

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Fri 8/5

22:29-8:35

2 stops51h 06m

Johannesburg OR Tambo

Sun 7/6

15:05-20:35

2 stops36h 30m

R21 112

Flights are sorted by cheapest return flights first.

Deals found on 10/4

Showing 1-10 of 39 resultsSorted by cheapest first
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R13 211). Flying from Panama to South Africa in December is currently the most expensive (average of R37 936). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Africa?

    For as low as R17 351, United Airlines can have you in South Africa from Panama in 27h 20m. The distance from Panama to South Africa is about 12194 km.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R13 211). Flying from Panama to South Africa in December is currently the most expensive (average of R37 936). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Africa

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to OR Tambo flights
San José to OR Tambo flights
Panama City to Cape Town flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama to South Africa?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to South Africa from Panama today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Panama to South Africa?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama to South Africa.

Can Cheapflights find flights from Panama to South Africa with no change fees?

Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama to South Africa become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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