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Cheap flights from Panama to South Africa from R9 133

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JNB
Feb 18 — Feb 251
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Keep the following information in mind while searching for Panama to South Africa flight deals. Data was last updated 19 January 2026.

Round-trip from

R15 413

One-way from

R9 133

Popular in

December

Cheapest in

January

Average price

R17 266
Lufthansa
  • Lufthansa
  • 16/2-23/2
  • 4 total stops
  • 73h 52m total
  • Panama to South Africa
Search Deals
United Airlines
  • United Airlines
  • 10/2
  • 2 total stops
  • 27h 05m total
  • Panama to South Africa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price (R98 982 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease (R32 470 potential savings vs. average return price).
Search Deals
Average for round-trip flights in January 2026
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Find flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa
Explore the most affordable flight options available from Panama to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 19 January 2026.

Mon 16/218:31
PTY
-
JNB
2 stops31h 59m
Lufthansa
Mon 23/219:45
JNB
-
PTY
2 stops41h 53m
Lufthansa
Deal found 17/1R15 413
Fri 30/19:30
PTY
-
CPT
2 stops25h 30m
United Airlines
Wed 4/220:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 19/1R16 331
Tue 3/37:55
PTY
-
CPT
2 stops27h 05m
United Airlines
Tue 10/320:50
CPT
-
PTY
2 stops44h 43m
United Airlines
Deal found 17/1R16 348
Wed 11/29:30
PTY
-
CPT
2 stops25h 30m
United Airlines
Thu 19/320:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 17/1R16 577
Mon 16/218:45
PTY
-
JNB
1 stop33h 05m
Turkish Airlines
Mon 23/219:05
JNB
-
PTY
1 stop29h 00m
Turkish Airlines
Deal found 17/1R17 364
Sun 15/27:55
PTY
-
JNB
2 stops27h 40m
United Airlines
Wed 4/319:45
JNB
-
PTY
2 stops40h 48m
United Airlines
Deal found 19/1R17 430
Wed 23/918:41
PTY
-
JNB
2 stops57h 24m
United Airlines
Wed 7/1019:00
JNB
-
PTY
2 stops56h 35m
United Airlines
Deal found 18/1R17 446
Mon 13/418:50
PTY
-
JNB
1 stop43h 30m
KLM
Mon 20/423:15
JNB
-
PTY
2 stops27h 30m
KLM
Deal found 16/1R18 118
Mon 9/29:11
PTY
-
CPT
1 stop23h 59m
United Airlines
Mon 23/218:45
CPT
-
PTY
2 stops42h 28m
United Airlines
Deal found 18/1R18 151
Wed 18/27:55
PTY
-
JNB
2 stops27h 40m
United Airlines
Sun 22/219:45
JNB
-
PTY
2 stops48h 46m
United Airlines
Deal found 17/1R18 184
Wed 18/318:09
PTY
-
CPT
2 stops37h 56m
United Airlines
Sun 22/318:45
CPT
-
PTY
2 stops42h 28m
United Airlines
Deal found 17/1R18 299
Tue 3/318:45
PTY
-
CPT
1 stop34h 05m
Turkish Airlines
Tue 10/317:15
CPT
-
PTY
1 stop33h 35m
Turkish Airlines
Deal found 17/1R18 496

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama to South Africa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 19 January 2026.
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

Fly from

Panama

Fly to

South Africa

Route

Depart

Return

Price

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Thu 5/3

18:31-9:30

2 stops31h 59m

Johannesburg OR Tambo

Thu 12/3

19:45-6:35

2 stops41h 50m

R15 413

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 30/1

8:55-18:00

2 stops26h 05m

Cape Town Intl

Wed 4/2

20:50-20:35

2 stops30h 45m

R16 331

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Tue 3/3

16:41-18:00

2 stops42h 19m

Cape Town Intl

Tue 10/3

20:50-20:35

1 stop30h 45m

R16 348

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

22:20-10:30

1 stop29h 10m

Johannesburg OR Tambo

Mon 20/4

18:00-18:25

1 stop31h 25m

R17 364

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 1/4

22:20-10:30

1 stop29h 10m

Johannesburg OR Tambo

Fri 3/4

18:00-20:25

1 stop33h 25m

R17 364

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 15/2

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

Wed 4/3

19:45-6:37

2 stops41h 52m

R17 430

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

18:50-21:20

1 stop43h 30m

Johannesburg OR Tambo

Mon 20/4

23:15-19:45

2 stops27h 30m

R18 118

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 18/2

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

Sun 22/2

19:45-13:31

2 stops48h 46m

R18 184

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 16/2

21:45-10:50

1 stop30h 05m

Johannesburg OR Tambo

Mon 23/2

19:05-17:05

2 stops29h 00m

R18 725

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 18/2

21:45-10:50

1 stop30h 05m

Johannesburg OR Tambo

Sun 22/2

19:05-17:05

2 stops29h 00m

R18 971

Flights are sorted by cheapest return flights first.

Deals found on 17/1

Showing 1-10 of 22 results
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 921). Flying from Panama to South Africa in November is currently the most expensive (average of R22 480). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Africa?

    For as low as R16 331, Lufthansa can have you in South Africa from Panama in 26h 05m. The distance from Panama to South Africa is about 11294 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 921). Flying from Panama to South Africa in November is currently the most expensive (average of R22 480). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Africa

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Cape Town flights
San José to OR Tambo flights
Panama City to OR Tambo flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama to South Africa?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to South Africa from Panama today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Panama to South Africa?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama to South Africa.

Can Cheapflights find flights from Panama to South Africa with no change fees?

Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama to South Africa become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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