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Cheap flights from Panama to South Africa from R8 360

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JNB
Feb 27 — Mar 61
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa
Explore the most affordable flight options available from Panama to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 28 January 2026.

Tue 3/218:31
PTY
-
CPT
2 stops33h 29m
Lufthansa
Mon 9/218:45
CPT
-
PTY
2 stops42h 53m
Lufthansa
Deal found 26/1R15 810
Tue 3/210:00
PTY
-
CPT
1 stop25h 00m
Multiple Airlines
Mon 9/218:45
CPT
-
PTY
2 stops42h 53m
Multiple Airlines
Deal found 26/1R15 922
Wed 4/37:55
PTY
-
JNB
2 stops27h 40m
United Airlines
Tue 10/319:45
JNB
-
PTY
2 stops41h 28m
United Airlines
Deal found 27/1R16 865
Sat 25/49:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Fri 1/517:55
CPT
-
PTY
2 stops50h 27m
United Airlines
Deal found 26/1R16 881
Wed 18/27:55
PTY
-
JNB
2 stops27h 40m
United Airlines
Sun 22/219:45
JNB
-
PTY
2 stops41h 28m
United Airlines
Deal found 25/1R16 993
Wed 4/321:45
PTY
-
JNB
1 stop30h 05m
Turkish Airlines
Tue 10/319:10
JNB
-
PTY
2 stops28h 55m
Turkish Airlines
Deal found 27/1R17 584
Mon 13/422:20
PTY
-
JNB
1 stop29h 10m
Turkish Airlines
Mon 20/418:00
JNB
-
PTY
2 stops31h 25m
Turkish Airlines
Deal found 27/1R17 616
Sat 9/522:29
PTY
-
CPT
2 stops52h 01m
United Airlines
Sun 24/517:55
CPT
-
PTY
2 stops33h 40m
United Airlines
Deal found 27/1R17 792
Wed 23/912:04
PTY
-
JNB
2 stops37h 31m
United Airlines
Wed 7/1019:00
JNB
-
PTY
2 stops42h 13m
United Airlines
Deal found 27/1R17 872
Mon 13/418:50
PTY
-
JNB
1 stop43h 30m
Multiple Airlines
Mon 20/418:00
JNB
-
PTY
1 stop32h 45m
Multiple Airlines
Deal found 26/1R18 032
Wed 23/918:27
PTY
-
JNB
2 stops31h 08m
Lufthansa
Wed 7/1019:00
JNB
-
PTY
2 stops42h 50m
Lufthansa
Deal found 26/1R18 303
Sat 9/518:50
PTY
-
CPT
1 stop43h 35m
KLM
Sun 24/523:15
CPT
-
PTY
1 stop24h 35m
KLM
Deal found 27/1R18 575

Find flight deals from Panama to South Africa

Keep the following information in mind while searching for Panama to South Africa flight deals. Data was last updated 28 January 2026.

Round-trip from

R16 865

One-way from

R8 360

Popular in

December

Cheapest in

January

Average price

R16 833
United Airlines
  • United Airlines
  • 4/3-10/3
  • 4 total stops
  • 69h 08m total
  • Panama to South Africa
Search Deals
Lufthansa
  • Lufthansa
  • 6/3
  • 2 total stops
  • 33h 29m total
  • Panama to South Africa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price (R94 074 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease (R30 852 potential savings vs. average return price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama to South Africa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 28 January 2026.
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

Fly from

Panama

Fly to

South Africa

Route

Depart

Return

Price

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 4/3

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

Tue 10/3

19:45-6:13

2 stops41h 28m

R16 865

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 25/4

19:25-15:20

2 stops60h 55m

Cape Town Intl

Sat 9/5

17:55-20:41

2 stops33h 46m

R16 881

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 25/4

9:13-15:20

1 stop23h 07m

Cape Town Intl

Fri 1/5

17:55-13:22

2 stops50h 27m

R16 881

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 18/2

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

Sun 22/2

19:45-6:13

2 stops41h 28m

R16 993

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 4/3

21:45-10:50

1 stop30h 05m

Johannesburg OR Tambo

Tue 10/3

19:10-17:05

2 stops28h 55m

R17 584

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

22:20-10:30

1 stop29h 10m

Johannesburg OR Tambo

Mon 20/4

18:00-18:25

2 stops31h 25m

R17 616

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 9/5

22:29-9:30

2 stops52h 01m

Cape Town Intl

Sun 24/5

17:55-20:35

2 stops33h 40m

R17 792

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

18:50-21:20

1 stop43h 30m

Johannesburg OR Tambo

Mon 20/4

18:00-19:45

1 stop32h 45m

R18 032

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 9/5

18:50-21:25

1 stop43h 35m

Cape Town Intl

Sun 24/5

23:15-16:50

1 stop24h 35m

R18 575

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 25/4

21:55-21:25

2 stops40h 30m

Cape Town Intl

Fri 1/5

7:40-19:45

2 stops43h 05m

R19 119

Flights are sorted by cheapest return flights first.

Deals found on 27/1

Showing 1-10 of 25 results
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 597). Flying from Panama to South Africa in July is currently the most expensive (average of R23 930). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Africa?

    For as low as R16 865, United Airlines can have you in South Africa from Panama in 27h 40m. The distance from Panama to South Africa is about 12194 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 597). Flying from Panama to South Africa in July is currently the most expensive (average of R23 930). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Africa

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Cape Town flights
Panama City to OR Tambo flights
San José to OR Tambo flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama to South Africa?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to South Africa from Panama today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Panama to South Africa?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama to South Africa.

Can Cheapflights find flights from Panama to South Africa with no change fees?

Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama to South Africa become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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