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Cheap flights from Panama to South Africa from R8 292

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/3. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JNB
Mar 16 — Mar 231
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa
Explore the most affordable flight options available from Panama to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 14 February 2026.

Sun 7/618:31
PTY
-
CPT
2 stops31h 59m
Lufthansa
Sun 21/617:55
CPT
-
PTY
2 stops43h 53m
Lufthansa
Deal found 10/2R15 929
Wed 8/418:31
PTY
-
JNB
2 stops31h 04m
Lufthansa
Thu 23/419:00
JNB
-
PTY
2 stops42h 48m
Lufthansa
Deal found 10/2R15 929
Wed 2/918:30
PTY
-
CPT
2 stops32h 00m
Lufthansa
Sat 19/917:55
CPT
-
PTY
2 stops43h 55m
Lufthansa
Deal found 13/2R15 945
Wed 26/819:25
PTY
-
CPT
2 stops36h 55m
United Airlines
Mon 14/919:50
CPT
-
PTY
2 stops28h 20m
United Airlines
Deal found 12/2R15 961
Mon 31/89:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Mon 21/919:50
CPT
-
PTY
2 stops29h 47m
United Airlines
Deal found 13/2R15 977
Tue 25/817:51
PTY
-
JNB
2 stops41h 39m
United Airlines
Tue 15/910:25
JNB
-
PTY
2 stops41h 10m
United Airlines
Deal found 13/2R16 153
Fri 4/922:29
PTY
-
JNB
2 stops39h 01m
United Airlines
Sun 20/915:05
JNB
-
PTY
2 stops29h 26m
United Airlines
Deal found 13/2R16 329
Thu 27/89:13
PTY
-
JNB
2 stops42h 52m
United Airlines
Tue 15/910:25
JNB
-
PTY
2 stops34h 06m
United Airlines
Deal found 12/2R16 409
Thu 27/88:11
PTY
-
CPT
2 stops24h 09m
United Airlines
Thu 17/919:50
CPT
-
PTY
2 stops31h 45m
United Airlines
Deal found 13/2R16 824
Sat 6/618:50
PTY
-
CPT
1 stop43h 35m
KLM
Sun 21/623:15
CPT
-
PTY
2 stops51h 30m
KLM
Deal found 10/2R16 840
Mon 31/89:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Sat 12/917:55
CPT
-
PTY
2 stops33h 46m
United Airlines
Deal found 13/2R16 888
Wed 26/88:11
PTY
-
JNB
2 stops27h 19m
United Airlines
Thu 10/919:00
JNB
-
PTY
2 stops42h 13m
United Airlines
Deal found 13/2R16 888

Find flight deals from Panama to South Africa

Keep the following information in mind while searching for Panama to South Africa flight deals. Data was last updated 14 February 2026.

Round-trip from

R15 929

One-way from

R8 292

Popular in

December

Cheapest in

January

Average price

R23 694
Lufthansa
  • Lufthansa
  • 7/6-21/6
  • 4 total stops
  • 75h 52m total
  • Panama to South Africa
Search Deals
Lufthansa
  • Lufthansa
  • 12/3
  • 2 total stops
  • 31h 59m total
  • Panama to South Africa
Search Deals
Highest demand for flights based on searches. 18% potential increase in price (R86 019 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease (R27 292 potential savings vs. average return price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama to South Africa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 14 February 2026.
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

Fly from

Panama

Fly to

South Africa

Route

Depart

Return

Price

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 7/6

18:31-9:30

2 stops31h 59m

Cape Town Intl

Sun 21/6

17:55-6:48

2 stops43h 53m

R15 929

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Wed 8/4

18:31-8:35

2 stops31h 04m

Johannesburg OR Tambo

Thu 23/4

19:00-6:48

2 stops42h 48m

R15 929

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Thu 16/4

8:11-18:30

2 stops27h 19m

Johannesburg OR Tambo

Sun 19/4

15:05-6:13

2 stops46h 08m

R16 153

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 8/6

18:50-21:25

1 stop43h 35m

Cape Town Intl

Sun 21/6

23:15-19:45

2 stops51h 30m

R16 840

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 6/6

18:50-21:25

1 stop43h 35m

Cape Town Intl

Sun 21/6

23:15-19:45

2 stops51h 30m

R16 840

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 7/6

22:29-15:20

1 stop33h 51m

Cape Town Intl

Sun 21/6

17:55-10:24

2 stops47h 29m

R16 888

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

9:39-18:30

2 stops25h 51m

Johannesburg OR Tambo

Mon 20/4

19:00-6:13

2 stops42h 13m

R16 888

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

22:20-10:30

1 stop29h 10m

Johannesburg OR Tambo

Mon 20/4

18:00-18:25

1 stop31h 25m

R17 016

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 13/4

21:55-11:05

1 stop30h 10m

Johannesburg OR Tambo

Mon 20/4

18:00-19:45

1 stop32h 45m

R17 176

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mon 8/6

21:55-17:20

2 stops36h 25m

Cape Town Intl

Sun 21/6

23:15-19:45

2 stops51h 30m

R17 240

Flights are sorted by cheapest return flights first.

Deals found on 11/2

Showing 1-10 of 34 results
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 798). Flying from Panama to South Africa in December is currently the most expensive (average of R36 748). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Africa?

    For as low as R16 153, Lufthansa can have you in South Africa from Panama in 27h 19m. The distance from Panama to South Africa is about 12194 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 798). Flying from Panama to South Africa in December is currently the most expensive (average of R36 748). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Africa

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to OR Tambo flights
Panama City to Cape Town flights
San José to OR Tambo flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama to South Africa?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to South Africa from Panama today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Panama to South Africa?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama to South Africa.

Can Cheapflights find flights from Panama to South Africa with no change fees?

Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama to South Africa become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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