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Cheap flights from Panama to South Africa from R8 756

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/5. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JNB
Apr 16 — Apr 231
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa
Explore the most affordable flight options available from Panama to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 17 March 2026.

Wed 11/1119:40
PTY
-
CPT
2 stops37h 30m
United Airlines
Sun 22/1120:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 14/3R16 740
Sun 26/49:13
PTY
-
CPT
2 stops24h 57m
United Airlines
Sun 3/520:00
CPT
-
PTY
3 stops31h 27m
United Airlines
Deal found 12/3R16 757
Wed 28/1019:40
PTY
-
CPT
2 stops37h 30m
United Airlines
Sun 8/1120:50
CPT
-
PTY
1 stop23h 41m
United Airlines
Deal found 16/3R16 891
Fri 28/822:29
PTY
-
CPT
1 stop33h 51m
United Airlines
Tue 15/920:00
CPT
-
PTY
2 stops49h 14m
United Airlines
Deal found 16/3R17 629
Wed 16/910:00
PTY
-
CPT
2 stops46h 20m
United Airlines
Sun 27/920:00
CPT
-
PTY
2 stops45h 33m
United Airlines
Deal found 13/3R17 646
Fri 28/822:29
PTY
-
CPT
1 stop33h 51m
United Airlines
Sun 13/917:55
CPT
-
PTY
2 stops33h 40m
United Airlines
Deal found 16/3R17 680
Wed 25/1118:41
PTY
-
CPT
1 stop38h 29m
United Airlines
Sun 6/1218:45
CPT
-
PTY
2 stops32h 50m
United Airlines
Deal found 13/3R17 696
Mon 13/48:02
PTY
-
JNB
2 stops27h 28m
United Airlines
Mon 20/419:00
JNB
-
PTY
2 stops42h 13m
United Airlines
Deal found 12/3R17 696
Tue 25/822:29
PTY
-
CPT
2 stops52h 01m
United Airlines
Tue 15/920:00
CPT
-
PTY
2 stops49h 14m
United Airlines
Deal found 16/3R18 569
Tue 25/818:41
PTY
-
CPT
2 stops55h 49m
United Airlines
Wed 16/917:55
CPT
-
PTY
2 stops33h 46m
United Airlines
Deal found 16/3R18 619
Sat 30/518:41
PTY
-
JNB
2 stops54h 54m
United Airlines
Fri 19/619:00
JNB
-
PTY
2 stops49h 33m
United Airlines
Deal found 12/3R18 653
Wed 26/89:13
PTY
-
CPT
2 stops41h 17m
United Airlines
Wed 9/917:55
CPT
-
PTY
2 stops32h 36m
United Airlines
Deal found 15/3R18 686

Find flight deals from Panama to South Africa

Keep the following information in mind while searching for Panama to South Africa flight deals. Data was last updated 17 March 2026.

Round-trip from

R16 757

One-way from

R8 756

Popular in

December

Cheapest in

March

Average price

R17 478
United Airlines
  • United Airlines
  • 26/4-3/5
  • 4 total stops
  • 56h 38m total
  • Panama to South Africa
Search Deals
Lufthansa
  • Lufthansa
  • 15/5
  • 2 total stops
  • 31h 04m total
  • Panama to South Africa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price (R103 195 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease (R30 846 potential savings vs. average return price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama to South Africa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 17 March 2026.
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest return flight
Fastest return journey

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sun 26/4

9:13-17:10

2 stops24h 57m

Cape Town Intl

Sun 3/5

20:00-20:41

2 stops31h 41m

R16 757

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 28/8

19:25-15:20

2 stops36h 55m

Cape Town Intl

Sun 13/9

20:00-20:27

2 stops31h 27m

R16 757

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Fri 28/8

22:29-15:20

1 stop33h 51m

Cape Town Intl

Tue 15/9

20:00-14:14

2 stops49h 14m

R17 629

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mon 31/8

9:13-18:30

2 stops26h 17m

Johannesburg OR Tambo

Tue 8/9

19:00-6:37

2 stops42h 37m

R17 696

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 22/4

9:39-17:10

2 stops24h 31m

Cape Town Intl

Sun 26/4

17:55-6:13

2 stops43h 18m

R17 831

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Wed 26/8

9:13-9:30

2 stops41h 17m

Cape Town Intl

Sat 12/9

17:55-6:13

2 stops43h 18m

R18 619

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sat 30/5

18:41-8:35

2 stops54h 54m

Johannesburg OR Tambo

Fri 19/6

19:00-13:33

2 stops49h 33m

R18 653

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Sun 31/5

22:29-8:35

2 stops51h 06m

Johannesburg OR Tambo

Fri 19/6

19:00-13:33

2 stops49h 33m

R18 653

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 9/5

18:50-21:25

1 stop43h 35m

Cape Town Intl

Sat 16/5

9:55-16:50

2 stops37h 55m

R19 458

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sat 9/5

22:29-9:30

2 stops52h 01m

Cape Town Intl

Sat 16/5

17:55-20:35

2 stops33h 40m

R19 542

Flights are sorted by cheapest return flights first.

Deals found on 12/3

Showing 1-10 of 22 resultsSorted by cheapest first
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R13 436). Flying from Panama to South Africa in December is currently the most expensive (average of R38 580). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Africa?

    For as low as R16 757, United Airlines can have you in South Africa from Panama in 24h 57m. The distance from Panama to South Africa is about 11294 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R13 436). Flying from Panama to South Africa in December is currently the most expensive (average of R38 580). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Africa

See prices for flight routes from nearby airports that may be better suited for you.
San José to OR Tambo flights
Panama City to OR Tambo flights
Panama City to Cape Town flights

Fly with Cheapflights

Find the best flight deals on Cheapflights, where travellers can enjoy low prices and a wide availability of flights to their desired destinations.

How does Cheapflights help users find flights from Panama to South Africa?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to South Africa from Panama today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Panama to South Africa?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama to South Africa.

Can Cheapflights find flights from Panama to South Africa with no change fees?

Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama to South Africa become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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