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Cheap flights from Panama to South Africa from R8 417

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 17/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — JNB
Feb 23 — Mrz 21
1 adult
1 adult, Economy, 0 bags

Cheap flight deals from Panama to South Africa

Enter your travel dates to find the best prices.

Cheapest flights from Panama to South Africa
Explore the most affordable flight options available from Panama to South Africa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 24 Januar 2026.

Fr 30/19:30
PTY
-
CPT
2 stops25h 30m
United Airlines
Mi 4/220:50
CPT
-
PTY
2 stops30h 45m
United Airlines
Deal found 22/1R16 044
Fr 30/18:55
PTY
-
CPT
2 stops26h 05m
United Airlines
Fr 6/220:50
CPT
-
PTY
1 stop23h 41m
United Airlines
Deal found 23/1R16 076
Fr 30/110:00
PTY
-
CPT
1 stop25h 00m
Air Canada
Fr 6/220:50
CPT
-
PTY
1 stop30h 45m
Air Canada
Deal found 23/1R16 850
Fr 30/122:29
PTY
-
JNB
2 stops37h 06m
United Airlines
Fr 6/219:45
JNB
-
PTY
2 stops31h 49m
United Airlines
Deal found 23/1R16 995
Mo 30/317:51
PTY
-
CPT
2 stops56h 39m
United Airlines
Di 28/420:00
CPT
-
PTY
2 stops40h 33m
United Airlines
Deal found 23/1R17 011
Mo 13/421:55
PTY
-
JNB
2 stops40h 25m
Multiple Airlines
Mo 20/418:00
JNB
-
PTY
1 stop32h 45m
Multiple Airlines
Deal found 22/1R17 544
Mo 5/109:13
PTY
-
CPT
1 stop23h 07m
United Airlines
Mo 26/1020:50
CPT
-
PTY
2 stops28h 48m
United Airlines
Deal found 23/1R17 834
So 1/218:45
PTY
-
JNB
1 stop44h 20m
KLM
Mo 16/219:20
JNB
-
PTY
2 stops28h 10m
KLM
Deal found 23/1R17 834
Mo 13/421:55
PTY
-
JNB
2 stops40h 25m
KLM
Mo 20/418:00
JNB
-
PTY
2 stops29h 50m
KLM
Deal found 22/1R17 866
Do 21/59:45
PTY
-
CPT
2 stops40h 45m
United Airlines
Fr 29/517:55
CPT
-
PTY
2 stops54h 15m
United Airlines
Deal found 22/1R17 931
Mi 23/912:04
PTY
-
JNB
2 stops37h 31m
United Airlines
Mi 7/1019:00
JNB
-
PTY
2 stops42h 13m
United Airlines
Deal found 22/1R17 995
Mo 30/320:10
PTY
-
CPT
1 stop32h 40m
Turkish Airlines
Di 28/416:35
CPT
-
PTY
1 stop34h 50m
Turkish Airlines
Deal found 23/1R18 511

Find flight deals from Panama to South Africa

Keep the following information in mind while searching for Panama to South Africa flight deals. Data was last updated 24 Januar 2026.

Round-trip from

R16 995

One-way from

R8 417

Popular in

December

Cheapest in

January

Average price

R16 979
United Airlines
  • United Airlines
  • 4/2-12/2
  • 4 total stops
  • 69h 08m total
  • Panama to South Africa
Search Deals
Lufthansa
  • Lufthansa
  • 16/2
  • 2 total stops
  • 31h 59m total
  • Panama to South Africa
Search Deals
Highest demand for flights based on searches. 19% potential increase in price (R95 730 potential increase over avg. return price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease (R31 397 potential savings vs. average return price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customise your flight search to find flights from Panama to South Africa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 594 507 searches. Data last updated 24 Januar 2026.
Use the filters below to find and compare flights from Panama to South Africa that are best for you.

Fly from

Panama

Fly to

South Africa

Route

Depart

Return

Price

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Mo 30/3

17:51-9:30

2 stops56h 39m

Cape Town Intl

Di 28/4

20:00-5:33

2 stops40h 33m

R17 011

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

So 29/3

10:00-15:20

2 stops46h 20m

Cape Town Intl

Sa 25/4

17:55-13:31

2 stops50h 36m

R17 011

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mo 13/4

21:55-21:20

2 stops40h 25m

Johannesburg OR Tambo

Mo 20/4

18:00-19:45

1 stop32h 45m

R17 544

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mo 13/4

21:55-21:20

2 stops40h 25m

Johannesburg OR Tambo

Mo 20/4

18:00-16:50

2 stops29h 50m

R17 866

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Do 21/5

9:45-9:30

2 stops40h 45m

Cape Town Intl

Fr 29/5

17:55-17:10

2 stops54h 15m

R17 931

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mi 18/2

7:55-18:35

2 stops27h 40m

Johannesburg OR Tambo

So 22/2

19:45-17:08

2 stops52h 23m

R18 753

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

Sa 28/3

22:29-9:30

2 stops52h 01m

Cape Town Intl

Sa 25/4

17:55-20:41

2 stops33h 46m

R18 785

Panama CityJohannesburg

PTY - JNB

PTYJNB

Panama City Tocumen Intl

Mi 18/2

21:45-10:50

1 stop30h 05m

Johannesburg OR Tambo

So 22/2

19:05-17:05

2 stops29h 00m

R19 172

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

So 29/3

20:05-11:50

1 stop32h 45m

Cape Town Intl

So 26/4

16:35-20:25

1 stop34h 50m

R19 511

Panama CityCape Town

PTY - CPT

PTYCPT

Panama City Tocumen Intl

So 29/3

22:55-15:20

2 stops33h 25m

Cape Town Intl

So 26/4

20:00-18:37

2 stops29h 37m

R19 559

Flights are sorted by cheapest return flights first.

Deals found on 22/1

Showing 1-10 of 27 results
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Best time to book a flight from Panama to South Africa

Have a flexible travel schedule? Discover the best time to fly to South Africa from Panama with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Africa

What is the cheapest month to book a flight from Panama to South Africa?

Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 706). Flying from Panama to South Africa in July is currently the most expensive (average of R24 139). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Africa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Africa?

    For as low as R19 511, United Airlines can have you in South Africa from Panama in 32h 45m. The distance from Panama to South Africa is about 11294 km. When browsing for deals, the options you’ll see will be for both direct flights and flights with stops.

  • Can I find deals for flights from Panama to South Africa that include hotel bookings?

    Yes. In addition to deals on Panama to South Africa flights, Cheapflights offers holiday packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Africa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Africa.

  • Can I find deals for business class flights from Panama to South Africa?

    Yes. Cheapflights offers flight deals from Panama to South Africa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Africa?

    Currently, September is the cheapest month in which you can book a flight from Panama to South Africa (average of R12 706). Flying from Panama to South Africa in July is currently the most expensive (average of R24 139). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Africa

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Cape Town flights
San José to OR Tambo flights
Panama City to OR Tambo flights

Fly with Cheapflights

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How does Cheapflights help users find flights from Panama to South Africa?

900+ travel sites are searched through when a user searches for a flight using Cheapflights. From the search interface, users can use filters to choose airlines, airports, flight times, cabin classes and more to their preference. Book your flight to South Africa from Panama today with Cheapflights!

Why should you use Cheapflights to find cheap flight tickets from Panama to South Africa?

It’s simple! Cheapflights, which is free to use for everyone, saves millions of users time and money every year by helping them find the cheapest and most suitable flights from Panama to South Africa.

Can Cheapflights find flights from Panama to South Africa with no change fees?

Certainly. Search results for flights to South Africa from Panama shown to you on Cheapflights can be narrowed down with different useful search filters, which includes flexible booking options.

Can Cheapflights notify me if prices for flights from Panama to South Africa become cheaper?

Yes, and it’s super simple to set up. Click the bell icon next to the flight deals above and provide a valid email address to enable Price Alerts. That’s it!

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